Biology, detection, and clinical implications of circulating tumor cells.
Biology, detection, and clinical implications of circulating tumor cells.
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DOI：
10.15252/emmm.201303698
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发表时间：
2015-01
影响因子：
11.1
通讯作者：
Pantel K
中科院分区：
文献类型：
--
作者：
Joosse SA;Gorges TM;Pantel K
癌症转移是癌症相关死亡的主要原因，并且肿瘤细胞通过血液循环的传播是重要的中间步骤，其也证实了从局部疾病到全身疾病的转变。因此，循环肿瘤细胞（CTC）的早期检测和表征作为监测和预防明显转移性疾病发展的一般策略是重要的。此外，CTC的连续分析可以提供关于全身疗法的有效性和进展的临床相关信息（例如，化疗、激素或用抗体或小抑制剂的靶向治疗）。尽管在CTC的检测和分子表征方面已经取得了许多进展，但仍然存在一些挑战，这些挑战限制了这种重要诊断方法的当前使用。在这篇综述中，我们讨论了肿瘤细胞传播的生物学，技术进步，以及CTC检测和表征的挑战和潜在的临床意义。
Cancer metastasis is the main cause of cancer-related death, and dissemination of tumor cells through the blood circulation is an important intermediate step that also exemplifies the switch from localized to systemic disease. Early detection and characterization of circulating tumor cells (CTCs) is therefore important as a general strategy to monitor and prevent the development of overt metastatic disease. Furthermore, sequential analysis of CTCs can provide clinically relevant information on the effectiveness and progression of systemic therapies (e.g., chemo-, hormonal, or targeted therapies with antibodies or small inhibitors). Although many advances have been made regarding the detection and molecular characterization of CTCs, several challenges still exist that limit the current use of this important diagnostic approach. In this review, we discuss the biology of tumor cell dissemination, technical advances, as well as the challenges and potential clinical implications of CTC detection and characterization.