Abnormalities in Itch Sensation and Skin Barrier Function in Atopic NC/Tnd Mice
Abnormalities in Itch Sensation and Skin Barrier Function in Atopic NC/Tnd Mice
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DOI：
10.1248/bpb.b13-00333
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发表时间：
2013-08-01
影响因子：
2
通讯作者：
Tanaka, Akane
中科院分区：
文献类型：
--
作者：
Amagai, Yosuke;Matsuda, Hiroshi;Tanaka, Akane
特应性皮炎（AD）是一种慢性炎症性皮肤病，以皮肤干燥和瘙痒为特征。遗传因素以及其他因素，包括皮肤屏障功能异常、瘙痒感觉神经过敏和免疫系统功能障碍，强烈影响 AD 的发病和恶化。最近，人们已经清楚瘙痒感与痛感密切相关。通过使用 NC/Tnd 小鼠（一种独特的人类 AD 自发动物模型），我们发现与两种标准品系 BALB/c 和 B6 小鼠相比，其对外部刺激的敏感性异常。特别是，在患有 AD 的传统 NC/Tnd 小鼠中，对瞬时受体电位 (TRP) V1 的刺激减少了抓挠行为，表明 TRPV1 调节剂治疗特应性瘙痒的可能性。该综述概述了通过使用一种新颖的实验动物瘙痒量化系统对 NC/Tnd 小鼠的瘙痒感觉和皮肤屏障功能进行的观察，这可能为未来的瘙痒研究带来巨大进展。
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dryness and itchy skin. Genetic factors as well as other factors, including abnormality in skin barrier function, hypersensitivity of itch sensory nerves, and dysfunction of the immune system, strongly affect the onset and exacerbation of AD. Recently, it has become clear that itch sensation is closely related to pain sensation. By using NC/Tnd mice, a unique spontaneous animal model for human AD, we found abnormalities in sensitivity against external stimuli as compared to two standard strains, BALB/c and B6 mice. Particularly, in conventional NC/Tnd mice with AD, stimulation against transient receptor potential (TRP) V1 reduced the scratching behavior, suggesting the possibility of a TRPV1 modulator in the treatment of atopic itch. The review outlines observations regarding itch sensation and skin barrier function in NC/Tnd mice by using a novel itch quantification system for the laboratory animals, which may bring great progress in the future study of itch.