EWSR1 rearrangement is present in a subset of myoepithelial tumors of salivary glands with variable morphology and does not correlate with clinical behavior
EWSR1 rearrangement is present in a subset of myoepithelial tumors of salivary glands with variable morphology and does not correlate with clinical behavior
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EWSR1 重排存在于形态各异的唾液腺肌上皮肿瘤亚群中，与临床行为无关
DOI：
10.1016/j.anndiagpath.2017.02.007
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发表时间：
2017-06-01
影响因子：
2
通讯作者：
Rao, Qiu
中科院分区：
文献类型：
--
作者：
Ni, Hao;Zhao, Pei-yu;Rao, Qiu
探讨EWSRI重排的唾液腺肌上皮肿瘤（MTs）是否表现出不同的形态学特征，以及EWSRI检测是否有助于区分唾液腺良性肌上皮肿瘤（BMTs）和恶性肌上皮肿瘤（MMTs）。我们通过组织学、免疫组织化学和分子分析检查了37例mt，其中24例为BMTs， 13例为MMTs。所有37例患者均对CKpan和至少一种肌上皮标志物免疫反应。37例MTs中有26例可进行EWSRI重排分析，结果15例BMTs中有4例检测到EWSRI基因断裂，11例MMTs中有4例检测到EWSRI基因断裂。另外，8例ewsr1重排的病例形态特征并不完全相似，包括4例透明细胞、1例浆细胞样细胞、1例梭形细胞、1例上皮样细胞和1例脊索样细胞。我们的研究表明，EWSRI重排存在于mt的一个子集中，具有可变的形态特征。此外，EWSRI重排的存在不能作为区分mmt和bbt的有力证据。(C) 2017爱思唯尔公司版权所有。
To investigate that whether myoepithelial tumors of salivary glands (MTs) with EWSRI rearrangement display distinctive morphological characteristics and whether EWSRI detection aids to distinguish malignant myoepithelial tumors (MMTs) from benign myoepithelial tumors (BMTs) of salivary glands. We examined 37 cases of MTs, including 24 BMTs, 13 MMTs, by histological, immunohistochemical, and molecular analysis. All of 37 cases were immunoreactive for CKpan, and at least one myoepithelial marker. 26 of 37 cases of MTs were available to be analyzed for EWSRI rearrangement, with the result that EWSRI gene break was detected in 4 cases of 15 BMTs, and 4 cases of 11 MMTs. In addition, the 8 EWSR1-rearranged cases displayed not exactly similar morphological features, covering 4 clear-cell cases, 1 plasmacytoid-cell case, 1 spindle -cell case, 1 epithelioid-cell case, and 1 chordoid-cell case. Our study proposed that EWSRI rearrangement was present in a subset of MTs, with variable morphological features. Moreover, the presence of EWSRI rearrangement could not be a forceful evidence to distinguish MMTs from BBTs. (C) 2017 Elsevier Inc. All rights reserved.