Neuropsychological function in schizophrenia. Selective impairment in memory and learning.
Neuropsychological function in schizophrenia. Selective impairment in memory and learning.
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DOI：
10.1001/archpsyc.1991.01810310036007
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发表时间：
1991-07
影响因子：
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通讯作者：
A. Saykin;R. Gur;R. Gur;P. Mozley;L. Mozley;S. Resnick;D. Kester;P. Stafiniak
中科院分区：
文献类型：
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作者：
A. Saykin;R. Gur;R. Gur;P. Mozley;L. Mozley;S. Resnick;D. Kester;P. Stafiniak
未用药的精神分裂症患者（根据DSM-III-R标准）（n = 36）和年龄匹配的正常对照组（n = 36），平衡的父母的社会经济地位，进行了一系列的标准化神经心理测试。与对照组相比，患者表现出广泛的损伤，与其他功能相比，记忆和学习存在选择性缺陷。在与额叶系统功能（抽象、语言流畅性和运动）相关的测试中未发现选择性损害。所观察到的模式是一致的颞海马系统的更大的参与，对弥漫性功能障碍的背景。虽然有记忆和学习障碍的报道，但与其他行为功能相比的选择性和相对严重性尚未得到认可。这种情况的特殊性值得进一步研究。这些发现支持了颞海马区在理解精神分裂症的病理生理学方面的假设重要性。
Unmedicated schizophrenic patients (according to DSM-III-R criteria) (n = 36) and age-matched normal controls (n = 36), balanced for parental socioeconomic status, were administered a battery of standardized neuropsychological tests. Patients showed generalized impairment relative to controls and a selective deficit in memory and learning compared with other functions. Selective impairment was not found on tests related to frontal system function (abstraction, verbal fluency, and motor). The observed pattern is consistent with greater involvement of the temporal-hippocampal system, against the background of diffuse dysfunction. Although impairment in memory and learning has been reported, the selectivity and relative severity compared with other behavioral functions have not been recognized. The specificity of this profile merits further examination. These findings lend support to the hypothesized importance of the temporal-hippocampal region in understanding the pathophysiology of schizophrenia.