Progesterone regulation of the occupied form of nuclear estrogen receptor.
Progesterone regulation of the occupied form of nuclear estrogen receptor.
复制标题
黄体酮对核雌激素受体占据形式的调节。
作者：
W. Okulicz;R. Evans;W. W. Leavitt
孕激素处理发情前期仓鼠后，子宫核部分中雌激素受体的总浓度迅速降低。孕激素选择性地作用于核雌激素受体的占据形式，对未占据形式的浓度没有影响。这一观察结果表明黄体酮通过控制雌激素受体复合物的核保留来调节雌激素的作用。
Total concentrations of estrogen receptor in the uterine nuclear fraction are reduced rapidly after progesterone treatment of the proestrous hamster. Progesterone acts selectively on the occupied form of the nuclear estrogen receptor, with no effect on the concentration of an unoccupied form. This observation indicates that progesterone modulates the action of estrogen by controlling nuclear retention of the estrogen-receptor complex.