Determinants of Nonadherence to a Single-Dose Nevirapine Regimen for the Prevention of Mother-to-Child HIV Transmission in Rwanda
Determinants of Nonadherence to a Single-Dose Nevirapine Regimen for the Prevention of Mother-to-Child HIV Transmission in Rwanda
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DOI：
10.1097/qai.0b013e31819001a3
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发表时间：
2009-02-01
影响因子：
3.6
通讯作者：
Asiimwe, Anita
中科院分区：
文献类型：
--
作者：
Delvaux, Therese;Elul, Batya;Asiimwe, Anita
目的：描述经验，并确定与不遵守单剂量奈韦拉平（SD-NVP）方案预防卢旺达艾滋病毒母婴传播（PMTCT）相关的因素。方法：2006年4月至5月，在12个预防母婴传播地点采用病例对照设计，我们采访了未坚持（n = 111）和坚持（n = 125）PMTCT预防方案的HIV感染妇女。不遵守定义为母亲和/或婴儿不inguishes SD-NVP在推荐的时间或根本没有和遵守作为母亲-婴儿对谁摄入它作为recommended.Results：只有61%的不遵守妇女在怀孕或分娩期间接受了SD-NVP。在接受SD-NVP的非依从性女性中，80%在推荐时间摄入，占所有非依从性女性的49%。只有7%的新生儿摄入了SD-NVP。多因素Logistic回归分析显示，未婚妇女、文化程度低的妇女、产前检查次数少于2次的妇女是危险因素。而那些在第一次产前检查后进行艾滋病毒检测的人更有可能不遵守预防母婴传播的预防措施。不透露一个人的艾滋病毒感染状况的人除了一个合作伙伴也与nonadvertisement在母婴pairs.Conclusions：社会人口因素，卫生服务提供因素，以及缺乏沟通和社会支持的PMTCT预防在卢旺达的不遵守。
Objectives: To describe experiences, and identify factors associated with nonadherence to a single-dose nevirapine (SD-NVP) regimen for the prevention of mother-to-child transmission (PMTCT) of HIV in Rwanda.Methods: In April to May 2006, using a case-control design at 12 PMTCT sites, we interviewed HIV-infected women who did not adhere (n = 111) and who adhered (n = 125) to the PMTCT prophylaxis regiment. Nonadherence was defined as mother and/or infant not ingesting SD-NVP at the recommended time or not at all and adherence as mother-infant pairs who ingested it as recommended.Results: Only 61% of nonadherent women had received SD-NVP during pregnancy or delivery. Among nonadherent women who received SD-NVP, 80% ingested it at the recommended time, representing 49% of all nonadherent women. Only 7% of their newborns ingested SD-NVP. Multivariate logistic regression showed that unmarried women, less educated women, women who made 2 or less antenatal care visits. and those offered HIV testing after their first antenatal care visit were more likely to be nonadherent to PMTCT prophylaxis. Not disclosing one's HIV status to someone aside from a partner was also associated with nonadherence in mother-infant pairs.Conclusions: Sociodemographic factors, health services delivery factors, and a lack Of communication and social support contributed to nonadherence to PMTCT prophylaxis in Rwanda.