Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality
Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality
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DOI：
10.1093/humrep/dei122
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发表时间：
2005-10-01
影响因子：
6.1
通讯作者：
Perreault, SD
中科院分区：
文献类型：
--
作者：
Rubes, J;Selevan, SG;Perreault, SD
背景：本研究考察了暴露于空气污染事件与精液质量改变之间的潜在关联。在捷克共和国的特普莱采地区，工业和家庭取暖用煤燃烧造成的空气污染在冬季比一年中的其他时候要严重得多，其峰值超过了美国的空气质量标准。方法：来自Teplice的年轻男性在2年内采样多达7次，以便在暴露于低和高空气污染期间后评估精液质量。进行常规精液分析（精子浓度、活力和形态）和精子非整倍体和染色质完整性测试，比较每个受试者的测量结果。根据环境空气污染监测数据，将暴露程度划分为高或低。结果：通过重复测量分析，根据精子染色质结构测定（SCSA），发现暴露于高空气污染时期（等于或高于美国空气质量标准上限）与DNA断裂精子百分比之间存在显著关联。其他精液测量与空气污染无关。结论：暴露于间歇性空气污染可能导致精子DNA损伤，从而增加男性介导的不孕症、流产和其他不良生殖结果的发生率。
BACKGROUND: This study examined potential associations between exposure to episodes of air pollution and alterations in semen quality. The air pollution, resulting from combustion of coal for industry and home heating in the Teplice district of the Czech Republic, was much higher during the winter than at other times of year with peaks exceeding US air quality standards. METHODS: Young men from Teplice were sampled up to seven times over 2 years allowing evaluation of semen quality after periods of exposure to both low and high air pollution. Routine semen analysis (sperm concentration, motility and morphology) and tests for sperm aneuploidy and chromatin integrity were performed, comparing measurements within each subject. Exposure was classified as high or low based on data from ambient air pollution monitoring. RESULTS: Using repeated measures analysis, a significant association was found between exposure to periods of high air pollution (at or above the upper limit of US air quality standards) and the percentage of sperm with DNA fragmentation according to sperm chromatin structure assay (SCSA). Other semen measures were not associated with air pollution. CONCLUSION: Exposure to intermittent air pollution may result in sperm DNA damage and thereby increase the rates of male-mediated infertility, miscarriage, and other adverse reproductive outcomes.