REPRESENTATION OF THE CECUM IN THE LATERAL DORSAL MOTOR NUCLEUS OF THE VAGUS NERVE AND COMMISSURAL SUBNUCLEUS OF THE NUCLEUS-TRACTUS-SOLITARII IN RAT
REPRESENTATION OF THE CECUM IN THE LATERAL DORSAL MOTOR NUCLEUS OF THE VAGUS NERVE AND COMMISSURAL SUBNUCLEUS OF THE NUCLEUS-TRACTUS-SOLITARII IN RAT
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DOI：
10.1002/cne.903040209
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发表时间：
1991-02-08
影响因子：
2.5
通讯作者：
MISELIS, RR
中科院分区：
文献类型：
--
作者：
ALTSCHULER, SM;FERENCI, DA;MISELIS, RR
腹腔迷走神经副支和腹腔迷走神经分支的运动纤维来源于迷走神经背侧运动核的外侧柱。这些分支还包含终止于孤束核内的感觉纤维。本研究通过使用霍乱毒素辣根过氧化物酶示踪剂来追踪肠的神经支配。在53只大鼠中，将示踪剂注射到胃，十二指肠，空肠，末端回肠，盲肠，或升colon.With所有盲肠注射，突出的逆行标记的细胞体发生在两侧的迷走神经背侧运动核的外侧柱以上，在，和以下的水平的最后区。外侧定位的神经元的树突投射内侧和rostrocaudally迷走神经的背侧运动核内和背内侧到内侧亚核和部分连合亚核的孤束核。感觉终末标记发生在吻侧最后区水平的背外侧连合亚核和最后区尾侧的内侧连合亚核。此外，在紧邻第四脑室的孤束核背内侧区的一个小的局限区域内，在最后区的正前方有感觉终末标记。胃注射标记的运动神经元的内侧柱的整个rostrocaudal范围内的迷走神经背侧运动核和感觉终端领域主要在亚核gelatinosus，与较低的强度标签延伸到尾部的内侧和腹侧连合亚核。胃运动神经元的树突在迷走神经背侧运动核内向吻尾侧和内侧投射，在孤束核内向背外侧投射。它们最明显的水平的吻侧区postrema的许多树突课程背外侧终止主要在subnucleus gelatinosus.Injections的十二指肠标记的迷走神经背侧运动核的内侧方面内的少数细胞。空肠，回肠，升结肠注射标记细胞稀疏的两侧迷走神经背侧运动核的侧面。迷走神经背侧复合体有明显的内脏分布：迷走神经背侧运动核有与终末器官神经支配相对应的中外侧结构;孤束核有一个代表内脏的喙尾轴，有一些重叠，对应于沿着消化道的喙尾定位和核内的终端。
Motor fibers of the accessory celiac and celiac vagal branches are derived from the lateral columns of the dorsal motor nucleus of the vagus nerve. These branches also contain sensory fibers that terminate within the nucleus of the tractus solitarii. This study traces the innervation of the intestines by using the tracer cholera toxin-horseradish peroxidase. In 53 rats, the tracer was injected into either the stomach, duodenum, jejunum, terminal ileum, cecum, or ascending colon.With all cecal injections, prominent retrograde labeling of cell bodies occurred bilaterally in the lateral columns of the dorsal motor nucleus of the vagus nerve above, at, and below the level of the area postrema. Dendrites of laterally positioned neurons projected medially and rostrocaudally within the dorsal motor nucleus of the vagus nerve and dorsomedially into both the medial subnucleus and parts of the commissural subnucleus of the nucleus of the tractus solitarii. Sensory terminal labeling occurred in the dorsolateral commissural subnucleus at the level of the rostral area postrema and the medial commissural subnucleus caudal to the area postrema. Additionally, there was sensory terminal labeling within a small confined area of the dorsomedial zone of the nucleus of the tractus solitarii immediately adjacent to the fourth ventricle at a level just anterior to the area postrema. Stomach injections labeled motoneurons of the medial column of the entire rostrocaudal extent of the dorsal motor nucleus of the vagus nerve and a sensory terminal field primarily in the subnucleus gelatinosus, with less intense labeling extending caudally into the medial and ventral commissural subnuclei. Dendrites of gastric motoneurons project rostrocaudally and mediolaterally within the dorsal motor nucleus of the vagus nerve and dorsolaterally within the nucleus of the tractus solitarii. They are most pronounced at the level of the rostral area postrema where many dendrites course dorsolaterally terminating primarily within the subnucleus gelatinosus.Injections of the duodenum labeled a small number of the cells within the medial aspects of the dorsal motor nucleus of the vagus nerve. Jejunal, ileal, and ascending colon injections labeled cells sparsely within the lateral aspects of the dorsal motor nucleus of the vagus nerve bilaterally. No afferent terminal labeling was evident after injection of these areas of the bowel.The dorsal vagal complex has a prominent viscerotopography: the dorsal motor nucleus of the vagus nerve has a mediolateral organization corresponding to end-organ innervation; the nucleus of the tractus solitarii has a rostrocaudal axis of visceral representation with some overlap corresponding to rostrocaudal positioning along the alimentary canal and mediolateral separation of terminals within the nucleus.