The role of Siglec-1 in HIV-1/macrophage interaction.
The role of Siglec-1 in HIV-1/macrophage interaction.
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DOI：
10.14800/macrophage.1435
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发表时间：
2016-10
期刊：
影响因子：
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通讯作者：
O. Jobe;Jiae Kim;M. Rao
中科院分区：
文献类型：
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作者：
O. Jobe;Jiae Kim;M. Rao
Although CD4 T-cells are a major target for HIV, recent work has demonstrated the ability of macrophages despite expressing relatively low levels of CD4, to be a target of the virus. Our recent study has found that the presence of growth factors not only play a role in the phenotype of these monocyte-derived-macrophages, but also are an important aspect of the permissiveness of these cells to infection. The work utilized cellular and biophysical methods to examine Siglec-1 on macrophages as a primary receptor in HIV-1 infection. These findings support the notion that Siglec-1 and macrophages and their interactions with the HIV-1 envelope should be considered in HIV-1 vaccine development.
