Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior.
Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior.
复制标题
设想迁移：实验分析和细胞行为建模中的数学。
DOI：
10.1016/j.ceb.2013.04.004
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发表时间：
2013
影响因子：
7.5
通讯作者：
Altschuler,StevenJ
中科院分区：
文献类型：
--
作者：
Zhang,ElizabethR;Wu,LaniF;Altschuler,StevenJ
细胞迁移的复杂性突出了将数学应用于生物学研究的力量和挑战。数学可以用来创建概括迁移的模型方程，它可以预测仅凭实验或直觉不容易发现的现象。或者，数学可以应用于以更好的分辨率解释复杂的数据集-可能使科学家能够在迁移细胞的典型噪声和异质性中识别微妙的模式。这两种方法之间的迭代是必要的，以揭示细胞迁移信号网络中的连接，以及了解这些连接产生的行为。在这里，我们回顾最近的定量分析和数学建模方法的细胞迁移问题。
The complex nature of cell migration highlights the power and challenges of applying mathematics to biological studies. Mathematics may be used to create model equations that recapitulate migration, which can predict phenomena not easily uncovered by experiments or intuition alone. Alternatively, mathematics may be applied to interpreting complex data sets with better resolution — potentially empowering scientists to discern subtle patterns amid the noise and heterogeneity typical of migrating cells. Iteration between these two methods is necessary in order to reveal connections within the cell migration signaling network, as well as to understand the behavior that arises from those connections. Here, we review recent quantitative analysis and mathematical modeling approaches to the cell migration problem.