Activation of corticotropin-releasing factor receptors from the basolateral or central amygdala increases the tonic immobility response in guinea pigs: An innate fear behavior
Activation of corticotropin-releasing factor receptors from the basolateral or central amygdala increases the tonic immobility response in guinea pigs: An innate fear behavior
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DOI：
10.1016/j.bbr.2011.06.027
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发表时间：
2011-11-20
影响因子：
2.7
通讯作者：
Andrade Leite-Panissi, Christie Ramos
中科院分区：
文献类型：
--
作者：
Donatti, Alberto Ferreira;Andrade Leite-Panissi, Christie Ramos
强直不动（TI）行为是与极端威胁情况（例如捕食者攻击）相关的先天反应。多项研究提供的证据表明促肾上腺皮质激素释放因子 (CRF) 在调节内分泌系统、防御行为和压力行为反应中发挥着重要作用。 TI已被证明与基础血浆皮质酮水平呈正相关。对 CRF 产生免疫反应的 CRF 受体和神经元存在于许多大脑区域，尤其是杏仁复合体中。先前的报告已证明基底外侧杏仁核 (BLA) 和中央杏仁核 (CeA) 参与 TI 反应。在这项研究中，我们评估了 BLA 和 CeA 的 CRF 系统对豚鼠 TI 反应的调节作用。 BLA 和 CeA 中 CRF 受体的激活促进了 TI 反应的增强。相反，通过 α-螺旋-CRF9-41 抑制这些受体会缩短 TI 反应的持续时间。此外，在旷场测试中，BIA 或 CeA 中 CRF 受体的激活或抑制都不会改变自发运动活动。这些数据表明，BLA 或 CeA 中 CRF 受体的激活可能会增强恐惧和焦虑，这可能是促进 TI 行为增加的因素之一。因此，这些数据支持 CRF 系统在控制情绪反应中的作用，特别是在调节先天恐惧方面。 (C) 2011 Elsevier B.V. 保留所有权利。
The tonic immobility (TI) behavior is an innate response associated with extreme threat situations such as a predator attack. Several studies have provided evidence suggesting an important role for corticotropin-releasing factor (CRF) in the regulation of the endocrine system, defensive behaviors and behavioral responses to stress. TI has been shown to be positively correlated with the basal plasma levels of corticosterone. CRF receptors and neurons that are immunoreactive to CRF are found in many cerebral regions, especially in the amygdaloid complex. Previous reports have demonstrated the involvement of the basolateral amygdaloid (BLA) and central amygdaloid (CeA) nuclei in the TI response. In this study, we evaluated the CRF system of the BLA and the CeA in the modulation of the TI response in guinea pigs. The activation of CRF receptors in the BLA and in the CeA promoted an increase in the TI response. In contrast, the inhibition of these receptors via alpha-helical-CRF9-41 decreased the duration of the TI response. Moreover, neither the activation nor inhibition of CRF receptors in the BIA or the CeA altered spontaneous motor activity in the open-field test. These data suggest that the activation of the CRF receptors in the BLA or the CeA probably potentiates fear and anxiety, which may be one of the factors that promote an increase in the TI behavior. Therefore, these data support the role of the CRF system in the control of emotional responses, particularly in the modulation of innate fear. (C) 2011 Elsevier B.V. All rights reserved.