Adiponectin and leptin in African Americans
Adiponectin and leptin in African Americans
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DOI：
10.1038/oby.2007.80
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发表时间：
2008-02-01
期刊：
影响因子：
6.9
通讯作者：
Sumner, Anne E.
中科院分区：
文献类型：
--
作者：
Considine, Robert V.;Premkumar, Ahalya;Sumner, Anne E.
目的：非裔美国人（AAs）有更少的内脏和更多的皮下脂肪比白人，从而脂联素和瘦素的关系，身体脂肪和胰岛素敏感性AA可能是不同的，从white.Methods和程序：69个非糖尿病AA（37名男性和32名女性），年龄33 +/- 1年参加。采用双能X线吸收法测定脂肪百分比，计算机断层扫描（CT）测定腹部内脏脂肪组织（VAT）和皮下脂肪组织（SAT）体积，稳态模型评估（HOMA）测定胰岛素敏感性。（1，619 +/- 177 cm（3）vs. 1，022 +/- 149 cm（3）; P = 0.01）;女性的体脂百分比较高（34.1 ± 1.4 vs. 24.0 ± 1.2; P < 0.0001），脂联素（15.8 +/- 1.2 μ g/ml vs. 10.4 +/- 0.8 μ g/ml; P = 0.0004）和瘦素（23.2 +/- 15.8 ng/ml vs. 9.2 +/- 7.2 ng/ml; P < 0.0001）。SAT和HOMA没有因为性别而不同。男性脂联素与VAT呈负相关（r =-0.41，P < 0.05），女性脂联素与VAT（r =-0.55，P < 0.01）、SAT（r =-0.35，P < 0.05）呈负相关。脂联素与HOMA呈负相关，男性（r =-0.38，P < 0.05），女性（r =-0.44，P < 0.05）。多元回归分析显示，性别（P = 0.02）、HOMA（P = 0.03）和VAT（P = 0.003）是脂联素的显著预测因素（adj R-2 = 0.38，P < 0.0001）。瘦素与VAT、SAT、脂肪百分比和HOMA呈显著正相关（男性r = 0.79、r = 0.86、r = 0.89和r = 0.53; P < 0.001），女性r = 0.62、r = 0.75、r = 0.83和r = 0.55; P < 0.01）。在多元回归分析中，VAT（P = 0.04）、体脂百分比（P < 0.0001）和性别（P = 0.01）是血清瘦素的显著预测因素（adj R-2= 0.82，P < 0.0001），而HOMA不是。虽然VAT和胰岛素敏感性是脂联素的重要决定因素，但VAT和体脂百分比决定瘦素。
Objective: African Americans (AAs) have less visceral and more subcutaneous fat than whites, thus the relationship of adiponectin and leptin to body fat and insulin sensitivity in AA may be different from that in whites.Methods and Procedures: Sixty-nine non-diabetic AA (37 men and 32 women), aged 33 +/- 1 year participated. The percent fat was determined by dual-energy X-ray absorptiometry, abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volume by computerized tomography (CT), and insulin sensitivity by homeostasis model assessment (HOMA).Results: VAT was greater in men (1,619 +/- 177 cm(3) vs. 1,022 +/- 149 cm(3); P = 0.01); women had a higher percentage of body fat (34.1 +/- 1.4 vs. 24.0 +/- 1.2; P < 0.0001), adiponectin (15.8 +/- 1.2 mu g/ml vs. 10.4 +/- 0.8 mu g/ml; P = 0.0004) and leptin (23.2 +/- 15.8 ng/ml vs. 9.2 +/- 7.2 ng/ml; P < 0.0001). SAT and HOMA did not differ because of the sex. Adiponectin negatively correlated with VAT (r = -0.41, P < 0.05) in men, and with VAT (r = -0.55, P < 0.01), and SAT (r = -0.35, P < 0.05) in women. Adiponectin negatively correlated with HOMA in men (r = -0.38, P < 0.05) and women (r = -0.44, P < 0.05). In multiple regression, sex (P = 0.02), HOMA (P = 0.03) and VAT (P = 0.003) were significant predictors of adiponectin (adj R-2 = 0.38, P < 0.0001). Leptin positively correlated with VAT, SAT, percent fat and HOMA in men (r = 0.79, r = 0.86, r = 0.89, and r = 0.53; P < 0.001) and women (r = 0.62, r = 0.75, r = 0.83, and r = 0.55; P < 0.01). In multiple regression VAT (P = 0.04), percent body fat (P < 0.0001) and sex (P = 0.01), but not HOMA were significant predictors of serum leptin (adj R-2= 0.82, P < 0.0001).Discussion: The relationship of adiponectin and leptin to body fat content and distribution in AA is dependent on sex. Although VAT and insulin sensitivity are significant determinants of adiponectin, VAT and percent body fat determine leptin.