AN OPEN-FIELD STUDY OF ANTIDEPRESSANT DRUGS
AN OPEN-FIELD STUDY OF ANTIDEPRESSANT DRUGS
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DOI：
10.1111/j.1600-0773.1989.tb00652.x
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发表时间：
1989-03-01
期刊：
影响因子：
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通讯作者：
GOTESTAM, KG
中科院分区：
文献类型：
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作者：
DAHL, CB;GOTESTAM, KG
八种精神药物，主要作用于儿茶酚胺能系统，进行了研究，在开放领域的设置。除一种药物外，所有药物的总体活性均随时间显著降低。仅32 mg/kg的吡贝地尔显示增加，而2 mg/kg显示随时间降低。氨奈普汀和诺米芬新显着增加和沙丁胺醇显着降低ampering和直立与剂量。对于维洛沙嗪、偏二甲胺、吡贝地尔和吡拉西坦，在试验剂量下未发现显著剂量效应。得出的结论是，临床报告的抗抑郁药疗效与选定的开放领域变量之间没有明显的相关性。然而，一些多巴胺能药物具有实质性的激活特性，这可能使它们产生依赖性。
Eight psychotropic drugs, mainly acting on the catecholaminergic systems, were investigated in an open field setting. All drugs but one showed a significant reduction in overall activity over time. Only piribedil at 32 mg/kg showed an increase, while 2 mg/kg showed a decrease over time. Amineptine and nomifensine significantly increased and salbutamol significantly decreased both ambulation and rearing with dose. For viloxazine, metapramine, piribedil and piracetam no significant dose effects were revealed at the doses tested. It is concluded that no clear correlation between clinical reported antidepressant efficacy and the selected open field variables can be demonstrated. However, some of the dopaminergic drugs have substantial activating properties, which might render them dependence-producing properties.