Very Short Echo Time Improves the Precision of Glutamate Detection at 3T in 1H Magnetic Resonance Spectroscopy
Very Short Echo Time Improves the Precision of Glutamate Detection at 3T in 1H Magnetic Resonance Spectroscopy
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DOI：
10.1002/jmri.22638
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发表时间：
2011-09-01
影响因子：
4.4
通讯作者：
Knight-Scott, Jack
中科院分区：
文献类型：
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作者：
Wijtenburg, S. Andrea;Knight-Scott, Jack
目的：探讨极短回波时间（TE）相位旋转蒸汽（PR-STEAM）序列检测谷氨酸的准确性。材料和方法：采用6.5 msec TE PR-STEAM, 40 msec TE PRESS, 72 msec TE STEAM，以及临床3T磁共振成像（MRI）系统上有效TE为105 msec的TE平均，从9名健康成人的前扣带回获得光谱数据。所有数据均使用LCModel进行量化，并以相对于总肌酸的比率报告。结果：所有序列谷氨酸Cramer-Rao下限均小于8%。6.5 msec TE PR-STEAM对谷氨酸的识别精度最高（变异系数（CV）为7.1%），其次是TE- averaging （CV为8.9%）、40 msec TE PRESS （CV为11.9%）和72 msec TE STEAM （CV为13.8%）。结论：在没有光谱编辑的情况下，使用非常短的TEs在3T时最好地检测到人脑中的谷氨酸。
Purpose: To examine the precision of glutamate detection using a very short echo time (TE) phase rotation STEAM (PR-STEAM) sequence.Materials and Methods: Spectrosopic data were acquired from the anterior cingulate gyrus in nine healthy adults using 6.5-msec TE PR-STEAM, 40-msec TE PRESS, 72-msec TE STEAM, and TE-Averaging with an effective TE of 105 msec on a clinical 3T magnetic resonance imaging (MRI) system. All data were quantified using LCModel and reported as ratios relative to total creatine.Results: Glutamate Cramer-Rao lower bounds were less than 8% for all sequences. The 6.5-msec TE PR-STEAM identified glutamate with the greatest precision (coefficient of variation (CV) of 7.1%), followed by TE-Averaging (CV of 8.9%), 40-msec TE PRESS (CV of 11.9%), and 72-msec TE STEAM (CV of 13.8%).Conclusion: In the absence of spectral editing, glutamate is best detected in the human brain at 3T using very short TEs.