Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements.
Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements.
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DOI：
10.1364/boe.2.002068
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发表时间：
2011-07-01
影响因子：
3.4
通讯作者：
St Lawrence K
中科院分区：
文献类型：
--
作者：
Diop M;Verdecchia K;Lee TY;St Lawrence K
神经重症监护的主要焦点是预防主要由缺血引起的继发性脑损伤。无创床旁连续监测脑血流（CBF）技术可以通过在脑损伤发生前检测缺血来改善患者管理。一个有前途的技术，用于这一目的是扩散相关光谱（DCS），因为它可以连续监测相对灌注的深部组织的变化。在这项研究中，DCS与时间分辨近红外技术（TR-NIR）相结合，可以直接测量CBF使用吲哚菁绿色作为流动示踪剂。通过这种组合，TR-NIR技术可用于将DCS数据转换为绝对CBF测量值。通过同时测量仔猪CBF变化来评估两种技术之间的一致性。观察到TR-NIR测量的CBF变化与DCS测量的缩放扩散系数变化之间存在强相关性（R2 = 0.93），斜率为1.05 ± 0.06，截距为6.4 ± 4.3%（平均值±标准误差）。
A primary focus of neurointensive care is the prevention of secondary brain injury, mainly caused by ischemia. A noninvasive bedside technique for continuous monitoring of cerebral blood flow (CBF) could improve patient management by detecting ischemia before brain injury occurs. A promising technique for this purpose is diffuse correlation spectroscopy (DCS) since it can continuously monitor relative perfusion changes in deep tissue. In this study, DCS was combined with a time-resolved near-infrared technique (TR-NIR) that can directly measure CBF using indocyanine green as a flow tracer. With this combination, the TR-NIR technique can be used to convert DCS data into absolute CBF measurements. The agreement between the two techniques was assessed by concurrent measurements of CBF changes in piglets. A strong correlation between CBF changes measured by TR-NIR and changes in the scaled diffusion coefficient measured by DCS was observed (R2 = 0.93) with a slope of 1.05 ± 0.06 and an intercept of 6.4 ± 4.3% (mean ± standard error).