Role of Shiga/Vero toxins in pathogenesis.
Role of Shiga/Vero toxins in pathogenesis.
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DOI：
10.1128/microbiolspec.ehec-0005-2013
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发表时间：
2014-06
影响因子：
3.7
通讯作者：
Obrig T
中科院分区：
文献类型：
--
作者：
Obata F;Obrig T
滋贺毒素（Stx）是滋贺毒素产生菌引起严重宿主反应包括肾脏和中枢神经系统（CNS）疾病的主要原因。大肠杆菌（STEC）感染。描述了Stx与不同真核细胞类型的相互作用。宿主对Stx和细菌脂多糖（LPS）的反应与STEC相关的溶血性尿毒综合征（HUS）的特征进行了比较。来自HUS和CNS疾病的动物模型，在体内，和真核细胞，在体外，数据进行了评估与人类HUS疾病。
Shiga toxin (Stx) is the primary cause of severe host responses including renal and central nervous system (CNS) disease in Shiga toxin-producing E. coli (STEC) infections. The interaction of Stx with different eukaryotic cell types is described. Host responses to Stx and bacterial lipopolysaccharide (LPS) are compared as related to the features of the STEC-associated Hemolytic Uremic Syndrome (HUS). Data derived from animal models of HUS and CNS disease, in vivo, and eukaryotic cells, in vitro, are evaluated in relation to HUS disease of humans.