Nucleolus-Targeted Photodynamic Anticancer Therapy Using Renal-Clearable Carbon Dots
Nucleolus-Targeted Photodynamic Anticancer Therapy Using Renal-Clearable Carbon Dots
复制标题
使用肾可清除碳点进行核仁靶向光动力抗癌治疗
DOI：
10.1002/adhm.202000607
复制
发表时间：
2020-06-16
影响因子：
10
通讯作者：
Wei, Xunbin
中科院分区：
文献类型：
--
作者：
Pang, Wen;Jiang, Pengfei;Wei, Xunbin
Photodynamic therapy (PDT), which utilizes light excited photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention in the last decades due to its unique advantages. In order to further enhance PDT effect, PSs are functionalized to target specific sub-cellular organelles, but most PSs cannot target nucleolus, which is demonstrated as a more efficient and ideal site for cancer treatment. Here, an effective carbon dots (C-dots) photosensitizer with intrinsic nucleolus-targeting capability, for the first time, is synthesized, characterized, and employed for in vitro and in vivo image-guided photodynamic anticancer therapy with enhanced treatment performance at a low dose of PS and light irradiation. The C-dots possess high ROS generation efficiency and fluorescence quantum yield, excellent in vitro and in vivo biocompatibility, and rapid renal clearance, endowing it with a great potential for future translational research.
