Comet: An open-source MS/MS sequence database search tool

Comet: An open-source MS/MS sequence database search tool
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DOI:
10.1002/pmic.201200439
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发表时间:
2013-01-01
期刊:
影响因子:
3.4
通讯作者:
Hoopmann, Michael R.
Hoopmann, Michael R.
中科院分区:
生物学3区
文献类型:
--
作者:
Eng, Jimmy K.;Jahan, Tahmina A.;Hoopmann, Michael R.

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蛋白质组学研究通常涉及通过MS/MS序列数据库搜索鉴定肽和蛋白质。因此,数据库搜索引擎是许多蛋白质组学研究小组不可或缺的工具。在这里,我们将Comet搜索引擎介绍给现有的商业和开源数据库搜索工具。Comet是开源的,免费提供的,并且基于已广泛使用多年的原始序列数据库搜索工具之一。
Proteomics research routinely involves identifying peptides and proteins via MS/MS sequence database search. Thus the database search engine is an integral tool in many proteomics research groups. Here, we introduce the Comet search engine to the existing landscape of commercial and open-source database search tools. Comet is open source, freely available, and based on one of the original sequence database search tools that has been widely used for many years.