Incidence of influenza-associated hospitalization in rural communities in western and northern India, 2010-2012: A multi-site population-based study
Incidence of influenza-associated hospitalization in rural communities in western and northern India, 2010-2012: A multi-site population-based study
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DOI：
10.1016/j.jinf.2014.08.015
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发表时间：
2015-02-01
影响因子：
28.2
通讯作者：
Chadha, Mandeep
中科院分区：
文献类型：
--
作者：
Hirve, Siddhivinayak;Krishnan, Anand;Chadha, Mandeep
背景：人们越来越认识到流感的全球负担，但来自印度的数据仍然很少。我们进行了一项多中心的基于人群的监测研究，以估计和比较2010- 2012年期间在Ballabgarh和Vadu的两个印度农村健康和人口监测系统（HDSS）站点的流感相关住院率。对所有住院进行前瞻性基于机构的监测在72个卫生设施进行了一次全面的检查（不包括创伤、选择性手术以及产科、眼科或精神病原因的检查）。在收集临床细节后，采集患者的鼻咽拭子并通过逆转录聚合酶链反应检测流感病毒。年度医疗保健利用调查（HUS）进行了HDSS家庭，以确定发生在非研究设施的住院比例，以调整住院错过了通过设施为基础的surveillance.Results：HUS显示，69%和67%的住院发生在研究设施在Ballabgarh和瓦杜，分别。总体而言，在参与机构入组了6004例因急性医学疾病住院的患者（1717例来自Ballabgarh; 4287例来自Vadu）。Vadu每年流感患者比例高于Ballabgarh（2010年：21% vs. 5%，p < 0.05; 2011年：18% vs. 5%，p < 0.05; 2012年：23% vs. 5%，p < 0.05）。Vadu的年度调整流感相关住院率（每10，000人20.3-51.6）比Ballabgarh（每10，000人4.4-6.3）高5-11倍。在这两个地点，2010年甲型H1N1 pdm 09和B流感占主导地位，2011年甲型H3 N2和B流感占主导地位，2012年甲型H1N1 pdm 09和B流感占主导地位。这将是在该国启动关于流感预防和控制战略的讨论的第一步。(C)2014由Elsevier Ltd代表英国感染协会发布。
Background: The global burden of influenza is increasingly recognized, but data from India remain sparse. We conducted a multi-site population-based surveillance study to estimate and compare rates of influenza-associated hospitalization at two rural Indian health and demographic surveillance system (HDSS) sites at Ballabgarh and Vadu during 2010-2012.Methods: Prospective facility-based surveillance for all hospitalizations (excluding those for trauma, elective surgery and obstetric, ophthalmic or psychiatric reasons) was conducted at 72 health facilities. After collection of clinical details, patients had nasopharyngeal swabs taken and tested by reverse transcription polymerase chain reaction for influenza viruses. Annual healthcare utilization surveys (HUS) were conducted in HDSS households to identify proportion of hospitalizations occurring at non-study facilities to adjust for hospitalizations missed through facility-based surveillance.Results: HUS showed that 69% and 67% of hospitalizations occurred at study facilities at Ballabgarh and Vadu, respectively. Overall, 6004 patients hospitalized with acute medical illness at participating facilities were enrolled (1717 from Ballabgarh; 4287 from Vadu). The proportion of patients with influenza was higher at Vadu than Ballabgarh annually (2010: 21% vs. 5%, p < 0.05; 2011: 18% vs. 5%, p < 0.05; 2012: 23% vs. 5%, p < 0.05). Annual adjusted influenza-associated hospitalization rates were 5-11 fold higher in Vadu (20.3-51.6 per 10,000) vs Ballabgarh (4.4-6.3 per 10,000). At both sites, influenza A/H1N1pdm09 and B predominated during 2010, A/H3N2 and B during 2011, and A/H1N1pdm09 and B during 2012.Conclusion: The markedly different influenza hospitalization rates by season and across communities in India highlight the need for sustained multi-site surveillance system for estimating national influenza disease burden. That would be the first step for initiating discussions around Influenza prevention and control strategies in the country. (C) 2014 Published by Elsevier Ltd on behalf of The British Infection Association.