mTOR signaling in cellular and organismal energetics
mTOR signaling in cellular and organismal energetics
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DOI：
10.1016/j.ceb.2014.12.001
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发表时间：
2015-04-01
影响因子：
7.5
通讯作者：
Hall, Michael N.
中科院分区：
文献类型：
--
作者：
Albert, Verena;Hall, Michael N.
哺乳动物TOR（mTOR）信号以细胞自主方式控制生长、代谢和能量稳态。最近的研究结果表明，一个组织中的mTOR信号传导也可以影响其他器官，从而以非细胞自主的方式影响全身代谢和能量稳态。因此，mTOR信号传导介导衰老并经常在代谢紊乱如肥胖症、糖尿病和癌症中失调并不奇怪。本文综述了mTOR对细胞和全身能量代谢的调节作用，特别是mTOR的非细胞自主功能。
Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can also affect other organs thereby affecting whole body metabolism and energy homeostasis in a non-cell autonomous manner. It is thus not surprising that mTOR signaling mediates aging and is often deregulated in metabolic disorders, such as obesity, diabetes and cancer. This review discusses the regulation of cellular and whole body energy metabolism by mTOR, with particular focus on the non-cell autonomous function of mTOR.