Contradictory Effects of β1-and α1-Aderenergic Receptor Blockers on Cardio-Ankle Vascular Stiffness Index (CAVI) - CAVI is Independent of Blood Pressure
Contradictory Effects of β1-and α1-Aderenergic Receptor Blockers on Cardio-Ankle Vascular Stiffness Index (CAVI) - CAVI is Independent of Blood Pressure
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DOI：
10.5551/jat.3582
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发表时间：
2011-01-01
影响因子：
4.4
通讯作者：
Takahashi, Mao
中科院分区：
文献类型：
--
作者：
Shirai, Kohji;Song, Mingling;Takahashi, Mao
目的：心踝血管僵硬指数（CAVI）是一个新参数，反映了主动脉、股动脉和胫动脉整体的僵硬度。CAVI的一个显著特点是在理论上与测量时的血压无关。但是，它还没有被实验证明。方法：采用β 1肾上腺素受体阻滞剂美托洛尔和α 1肾上腺素受体阻滞剂多沙唑嗪进行药理学研究，并与臂踝脉搏波传导速度（baPWV）进行比较。这两种药物均给予12名健康志愿者。使用VaSera每隔1小时测量CAVI和baPWV，持续6小时。当12名健康志愿者服用美托洛尔（80 mg）时，收缩压从131.4 ± 4.5 mmHg降至118.3 ± 4.1 mmHg舒张压从85.3 ± 4.0 mmHg降至75.3 ± 3.0 mmHg（p< 0.05）。baPWV从13.93 +/- 0.46降至12.46 +/- 0.49 m/sec（p< 0.05），但CAVI没有变化（8.16 +/- 0.29至8.24 +/- 0.27）（p = 0.449）。每个时间点的Δ baPWV与Δ收缩压和Δ舒张压均显著相关，但Δ CAVI与任一Δ血压均不相关。当多沙唑嗪（4 mg）给予相同的男性时，收缩压在第3小时从130.2 ± 4.6 mmHg降至117.2 ± 4.8 mmHg（p< 0.05）。舒张压也从85.1 +/- 4.1降至74.2 +/- 3.9 mmHg（p< 0.05）。baPWV从13.98 +/- 0.68下降到12.25 +/- 0.53 m/sec（p< 0.05）。CAVI从8.15 ± 0.28下降到7.18 ± 0.37（P< 0.05），提示CAVI不受测量时血压的直接影响，而受平滑肌细胞收缩力变化的影响。
Aim: The cardio-ankle vascular stiffness index (CAVI) is a new parameter that reflects the stiffness of the aorta, femoral artery and tibial artery as a whole. One of its conspicuous features is that CAVI is independent of blood pressure at measuring time, theoretically. But, it has not been experimentally proved yet. For confirmation, pharmacological studies were performed comparing with brachial-ankle pulse wave velocity (baPWV).Methods: Used drugs were a beta 1-adrenoceptor blocker, metoprorol and an alpha 1-adrenoceptor blocker doxazosin. Both were administered to 12 healthy volunteer men. CAVI and baPWV were measured every one hour for 6 hours using VaSera.Results: When metoprolol (80 mg) was administered to 12 healthy volunteer men, systolic blood pressure decreased from 131.4 +/- 4.5 to118.3 +/- 4.1 mmHg (mean +/- SE) (p< 0.05) at the 3rd hour, and diastolic blood pressure decreased from 85.3 +/- 4.0 to 75.3 +/- 3.0mmHg (p< 0.05). baPWV decreased from 13.93 +/- 0.46 to 12.46 +/- 0.49 m/sec (p< 0.05), significantly, but CAVI did not change (8.16 +/- 0.29 to 8.24 +/- 0.27) (p = 0.449). Delta baPWV at each time was significantly correlated with both Delta systolic and Delta diastolic blood pressures, but Delta CAVI was not correlated with either Delta blood pressure. When doxazosin (4 mg) was administered to the same men, systolic blood pressure decreased from 130.2 +/- 4.6 to117.2 +/- 4.8 mmHg (p< 0.05) at the 3rd hour. Diastolic blood pressure also decreased from 85.1 +/- 4.1 to 74.2 +/- 3.9 mmHg (p< 0.05). baPWV decreased from 13.98 +/- 0.68 to 12.25 +/- 0.53 m/sec (p< 0.05), significantly. CAVI also decreased from 8.15 +/- 0.28 to 7.18 +/- 0.37 (p< 0.05), significantly.Conclusion: These results suggested that CAVI was not affected by blood pressure at the measuring time directly, but affected by the changes of contractility of smooth muscle cells.