Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment.
Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment.
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DOI：
10.1002/hed.21975
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发表时间：
2013-02
影响因子：
2.9
通讯作者：
Schwartz, David L.
中科院分区：
文献类型：
--
作者：
Lucs, Alexandra V.;Saltman, Benjamin;Chung, Christine H.;Steinberg, Bettie M.;Schwartz, David L.
关键词：
头颈肿瘤学家传统上依赖临床肿瘤特征和患者特征来指导个体患者的护理。随着手术、放射治疗和全身治疗的发展，在解剖学上变得更加精确和机械特异性，对于这种历史上使人衰弱的癌症来说，改善治愈和功能性患者康复的机会从未如此有希望。然而，个性化治疗必须伴随着复杂的患者选择，以将先进疗法的应用分类为理想的患者候选者。在本专着中，我们回顾了头颈癌生物标志物开发的当前进展、研究主题和面临的主要挑战，旨在使个性化头颈癌治疗成为临床现实。
Head and neck oncologists have traditionally relied upon clinical tumor features and patient characteristics to guide care of individual patients. As surgical, radiotherapeutic, and systemic treatments have evolved to become more anatomically precise and mechanistically specific, the opportunity for improved cure and functional patient recovery has never been more promising for this historically debilitating cancer. However, personalized treatment must be accompanied by sophisticated patient selection to triage the application of advanced therapies towards ideal patient candidates. In this monograph, we review current progress, investigative themes, and key challenges facing head and neck cancer biomarker development intended to make personalized head and neck cancer treatment a clinical reality.
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影响因子：
6.4
作者：
Chang, Steven S.;Jiang, Wei Wen;Smith, Ian;Poeta, Luana M.;Begum, Shahnaz;Glazer, Chad;Shan, Shannon;Westra, William;Sidransky, David;Califano, Joseph A.
通讯作者：
Califano, Joseph A.
DOI：
10.1158/1078-0432.ccr-08-3131
发表时间：
2009-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Avissar M;Christensen BC;Kelsey KT;Marsit CJ
通讯作者：
Marsit CJ
影响因子：
45.3
作者：
Baselga, J;Trigo, JM;Eckardt, A
通讯作者：
Eckardt, A
影响因子：
5.7
作者：
Byers LA;Holsinger FC;Kies MS;William WN;El-Naggar AK;Lee JJ;Hu J;Lopez A;Tran HT;Yan S;Du Z;Ang KK;Glisson BS;Raso MG;Wistuba II;Myers JN;Hong WK;Papadimitrakopoulou V;Lippman SM;Heymach JV
通讯作者：
Heymach JV
影响因子：
158.5
作者：
Bonner, JA;Harari, PM;Ang, KK
通讯作者：
Ang, KK