BORON NEUTRON-CAPTURE THERAPY OF INTRACEREBRAL RAT GLIOSARCOMAS
BORON NEUTRON-CAPTURE THERAPY OF INTRACEREBRAL RAT GLIOSARCOMAS
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DOI：
10.1073/pnas.87.24.9808
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发表时间：
1990-12-01
影响因子：
11.1
通讯作者：
SLATKIN, DN
中科院分区：
文献类型：
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作者：
JOEL, DD;FAIRCHILD, RG;SLATKIN, DN
观察了硼中子俘获治疗（BNCT）对脑内植入的大鼠胶质瘤的治疗效果。通过从肿瘤起始后第11天至第14天（第0天）以每天45-50 μ g 10 B/g体重的速率连续输注巯基硼烷二聚体Na 410 B24 H22 S2，实现10 B在肿瘤中的优先积累。该输注时间表导致12只患有神经胶质瘤的大鼠的组中平均血液10 B浓度为35 μ g/ml，并且在用BNCT治疗的类似患有神经胶质瘤的大鼠的组中平均血液10 B浓度为45 μ g/ml。在这两组中估计的肿瘤10 B水平分别为26和34 μ g/g。在第14天，将硼处理的和未硼处理的大鼠暴露于来自Brookhaven医学研究反应堆的5.0或7.5MW·min的辐射，该反应堆产生约2.0 × 104的热中子注量。1012或约3.0 ×10 ~（12）N/cm ~ 2。未处理大鼠的中位启动后存活时间为21天。单独的反应堆辐射使中位启动后存活时间增加到26（5.0 MW·min）或28（7.5 MW·min）天。接受5 MW·min的BNCT的12只大鼠具有60天的中位起始后存活时间。这些动物中有两只存活超过15个月。在7.5MW·min组中，由于10只动物中有6只在BNCT后存活>10个月，因此无法计算平均存活时间。两个BNCT组中肿瘤的估计辐射剂量分别为14.2和25.6戈伊当量。类似的胶质瘤大鼠接受15.0或22.5戈伊的250千伏峰值X射线治疗后，肿瘤发生后的中位生存时间分别仅为26或31天。
The efficacy of boron neutron capture therapy (BNCT) for the treatment of intracerebrally implanted rat gliosarcomas was tested. Preferential accumulation of 10B in tumors was achieved by continuous infusion of the sulfhydryl borane dimer, Na410B24H22S2, at a rate of 45-50 .mu.g of 10B per g of body weight per day from day 11 to day 14 after tumor initiation (day 0). This infusion schedule resulted in average blood 10B concentrations of 35 .mu.g/ml in a group of 12 gliosarcoma-bearing rats and 45 .mu.g/ml in a group of similar gliosarcoma-bearing rats treated by BNCT. Estimated tumor 10B levels in these two groups were 26 and 34 .mu.g/g, respectively. On day 14, boron-treated and non-boron-treated rats were exposed to 5.0 or 7.5 MW.cntdot.min of radiation from the Brookhaven Medical Research Reactor that yielded thermal neutron fluences of .apprxeq.2.0 .times. 1012 or .apprxeq.3.0 .times. 1012 n/cm2, respectively, in the tumors. Untreated rats had a median postinitiation survival time of 21 days. Reactor radiation alone increase median postinitiation survival time to 26 (5.0 MW.cntdot.min) or 28 (7.5 MW.cntdot.min) days. The 12 rats that received 5 MW.cntdot.min of BNCT had a median postinitiation survival time of 60 days. Two of these animals survived >15 months. In the 7.5 MW.cntdot.min group, the median survival time is not calculable since 6 of the 10 animals remain alive >10 months after BNCT. The estimated radiation doses to tumors in the two BNCT groups were 14.2 and 25.6 Gy equivalents, respectively. Similar gliosarcoma-bearing rats treated with 15.0 or 22.5 Gy of 250-kilovolt peak x-rays had median survival times of only 26 or 31 days, respectively, after tumor initiation.