Effects of the Combination Treatment of Raloxifene and Alendronate on the Biomechanical Properties of Vertebral Bone
Effects of the Combination Treatment of Raloxifene and Alendronate on the Biomechanical Properties of Vertebral Bone
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DOI：
10.1002/jbmr.197
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发表时间：
2011-02-01
影响因子：
6.2
通讯作者：
Burr, David B.
中科院分区：
文献类型：
--
作者：
Diab, Tamim;Wang, Jason;Burr, David B.
雷洛昔芬（RAL）和阿仑膦酸钠（ALN）通过不同的机制改善骨的生物力学性能。本研究旨在探讨RAL和ALN联合治疗对椎体骨生物力学特性的影响。将6月龄Sprague-Dawley大鼠（n = 80）随机分为5个实验组（假手术组、OVX组、OVX + RAL组、OVX + ALN组和OVX + RAL + ALN组; n 16/组）。安乐死后，评估椎体的结构和衍生材料生物力学性能。对松质骨进行密度和动态组织形态测量。结果表明，综合治疗可改善脊柱骨的结构生物力学性能。OVX + RAL和OVX + ALN组的刚度和极限载荷显著低于假手术组，但RAL + ALN联合治疗与假手术组无显著差异。此外，OVX + RAL + ALN组是唯一一个极限负荷显著高于OVX动物的药物治疗组（p
Raloxifene (RAL) and alendronate (ALN) improve the biomechanical properties of bone by different mechanisms. The goal here was to investigate the effects of combination treatment of RAL and ALN on the biomechanical properties of vertebral bone. Six-month-old Sprague-Dawley rats (n = 80) were randomized into five experimental groups (sham, OVX, OVX + RAL, OVX + ALN, and OVX + RAL + ALN; n 16/group). Following euthanization, structural and derived material biomechanical properties of vertebral bodies were assessed. Density and dynamic histomorphometric measurements were made on cancellous bone. The results demonstrate that the structural biomechanical properties of vertebral bone are improved with the combination treatment. Stiffness and ultimate load of the OVX + RAL and OVX + ALN groups were significantly lower than those of sham animals, but the combination treatment with RAL + ALN was not significantly different from sham. Furthermore, the OVX + RAL + ALN group was the only agent-treated group in which the ultimate load was significantly higher than that in OVX animals (p