Spread of antibiotic resistance with food-borne pathogens
Spread of antibiotic resistance with food-borne pathogens
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DOI：
10.1007/s000180050022
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发表时间：
1999-11-30
影响因子：
8
通讯作者：
Teuber, M
中科院分区：
文献类型：
--
作者：
Teuber, M
这篇简短的综述总结了沙门氏菌等常见食源性病原体的抗生素耐药性数据，大肠杆菌，弯曲杆菌属，单核细胞增生李斯特菌、产气荚膜梭菌、金黄色葡萄球菌和凝固酶阴性葡萄球菌。作为过去几年文献的闪光灯，它提供了充分的证据表明抗生素耐药性特征已经进入农场动物的微生物区系和由它们生产的食物。对耐药性基因的分子分析（如有）表明，食物微生物菌群并没有与其人类对应菌群分开，体外和少数情况下体内的耐药性基因接合转移已得到证实。例如，对于鼠伤寒沙门氏菌，对四环素类的耐药性从1948年的零增加到某些流行性鼠伤寒沙门氏菌群体中的98%水平。1998年，鼠伤寒沙门氏菌DT 104。生肉和牛奶中食源性病原体的高发病率，以及农业中抗生素在治疗、预防和营养方面的大量应用，揭示了一个全球性的抗生素耐药性问题。如果耐药基因通过食物链不断涌入人体微生物群落，人类医学中的耐药问题将无法解决。
This short review summarizes data on antibiotic resistance profiles of common food-borne pathogens like Salmonella sp., Eschevichia coli, Campylobacter sp., Listeria monocytogenes, Clostridium perfringens, Staphylococcus aureus, and coagulase-negative staphylococci. As a flashlight on the literature of the last few years, it provides ample evidence that antibiotic resistance traits have entered the microflora of farm animals and the food produced from them. Molecular analysis of the resistance genes, where available, shows that the food microflora is not separated from its human counterpart and conjugative transfer of resistance genes has been demonstrated in vitro and in a few cases in vivo. For example, for Salmonella typhimurium, resistance towards tetracyclines has increased from zero in 1948 to a 98% level in certain epidemic populations of S. typhimurium DT104 in 1998. The high incidence of food-borne pathogens in raw meat and milk together with a high level of therapeutic, prophylactic and nutritional application of antibiotics in agriculture reveals an antibiotic resistance problem of global dimensions. The resistance problem in human medicine will not be solved if there is a constant influx of resistance genes into the human microflora via the food chain.