Retention of the expression of E-cadherin and catenins is associated with shorter survival in grade III ductal carcinoma of the breast
Retention of the expression of E-cadherin and catenins is associated with shorter survival in grade III ductal carcinoma of the breast
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DOI：
10.1002/path.831
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发表时间：
2001-04-01
影响因子：
7.3
通讯作者：
Hanby, AM
中科院分区：
文献类型：
--
作者：
Gillett, CE;Miles, DW;Hanby, AM
许多研究已经调查了E-钙粘蛋白/连环蛋白轴和乳腺癌生物学之间的关系，然而，与其他肿瘤系统的研究不同，这些研究显示了下调和生存不良之间的关系，在乳腺癌中没有明确的关联。由于越来越多的证据表明，无特殊类型的导管癌（NST）代表了一组不同的生物学，本研究的重点是III级导管癌，以减少研究人群的异质性。共研究了470例乳腺肿瘤。连续切片用抗体标记，所述抗体识别E-钙粘蛋白和与其相互作用的臂蛋白：α-、β-和γ-连环蛋白。膜结合和细胞质E-钙粘蛋白和膜结合α-连环蛋白表达与雌激素受体（ER）阳性状态相关，γ-连环蛋白与ER阴性状态相关，令人惊讶的是，所有三种都与生存率差相关。综上所述，这些发现表明，保守的E-钙粘蛋白/连环蛋白轴可能在决定III级乳腺癌的不良结局中发挥作用。版权所有（C）2001约翰威利父子有限公司
Many studies have investigated the relationship between the E-cadherin/catenin axis and breast cancer biology and yet, unlike the studies in other tumour systems, which have shown a relationship between down-regulation and poor survival, no clear association has emerged in breast. Since accumulating evidence suggests that ductal carcinoma of no special type (NST) represents a diverse group of biologies, this study has focused on grade III ductal carcinoma, in order to reduce the heterogeneity of the study population. A total of 470 breast tumours were studied. Consecutive sections were labelled with antibodies, which recognize E-cadherin and the arm proteins with which it interacts: alpha-, beta-, and gamma -catenin. Membrane-bound and cytoplasmic E-cadherin and membrane-bound alpha -catenin expression were associated with a positive oestrogen receptor (ER) status, gamma -catenin with a negative ER status, and, surprisingly, all three with poor survival. Taken together, these findings suggest that a conserved E-cadherin/catenin axis may play a part in determining adverse outcome in grade III breast carcinoma. Copyright (C) 2001 John Wiley & Sons, Ltd.