Acute inhibition of mGluR5 disrupts behavioral flexibility.
Acute inhibition of mGluR5 disrupts behavioral flexibility.
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mGluR5 的急性抑制会破坏行为灵活性。
DOI：
10.1016/j.nlm.2016.01.004
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发表时间：
2016
影响因子：
2.7
通讯作者：
Wang,Hongbing
中科院分区：
文献类型：
--
作者：
Sethna,Ferzin;Wang,Hongbing
条件提示有时会引起适应不良反应，如创伤后应激障碍（PTSD）。缺乏有效的恐惧消退，这涉及到抑制性学习的过程，被假设与创伤后应激障碍有关。在这项研究中，我们测试了急性药理学抑制mGluR 5活性对恐惧记忆和空间记忆消退的影响。腹膜内注射mGluR 5（代谢型谷氨酸受体5）拮抗剂MPEP [2-甲基-6-（苯乙炔基）吡啶盐酸盐]允许检索，但阻止了小鼠背景恐惧记忆的消退。在不改变自发活动的情况下，MPEP抑制了情境恐惧记忆的获得，但不抑制其巩固。此外，在Morris水迷宫实验中，MPEP的给药阻断了空间记忆的消退。我们的数据表明，mGluR 5在调节行为灵活性的某些方面的必要作用。
Conditioned cues can sometimes elicit maladaptive responses as seen in the post-traumatic stress disorder (PTSD). Lack of effective fear extinction, which involves a process of inhibitory learning, is hypothesized to associate with PTSD. In this study, we tested the effect of acute pharmacological inhibition of mGluR5 activity on the extinction of fear memory and spatial memory. Intraperitoneal injection of the mGluR5 (metabotropic glutamate receptor 5) antagonist MPEP [2-Methyl-6-(phenylethynyl) pyridine hydrochloride] allowed the retrieval but prevented the extinction of contextual fear memory in mice. Without altering locomotor activity, MPEP inhibited the acquisition but not the consolidation of contextual fear memory. Further, administration of MPEP blocked the extinction of spatial memory in the Morris water maze paradigm. Our data suggest a necessary role of mGluR5 in regulating certain aspects of behavioral flexibility.