Symptom clusters and their impact on quality of life in multiple myeloma survivors: Secondary analysis of BMT CTN 0702 trial.
Symptom clusters and their impact on quality of life in multiple myeloma survivors: Secondary analysis of BMT CTN 0702 trial.
复制标题
症状群及其对多发性骨髓瘤幸存者生活质量的影响：BMT CTN 0702 试验的二次分析。
DOI：
10.1111/bjh.19326
复制
发表时间：
2024
影响因子：
6.5
通讯作者：
D'Souza,Anita
中科院分区：
文献类型：
--
作者：
Brazauskas,Ruta;Flynn,Kathryn;Krishnan,Amrita;Landau,Heather;Giralt,Sergio;Pasquini,MarceloC;Stadtmauer,EdwardA;D'Souza,Anita
自体造血细胞移植（autoHCT）和连续移植后维持治疗是符合移植条件的多发性骨髓瘤（MM）患者的标准治疗。我们试图使用BMT CTN 0702随机对照试验的数据描述autoHCT后MM患者中发生的症状负担并识别症状群，该试验比较了758例MM患者autoHCT后三种治疗干预措施的结局。我们分析了在入组时通过FACT‐BMT问卷评估的个体移植相关症状，并在autoHCT后4年每年进行一次。我们还描述了个体症状和症状群对生活质量（QoL）的影响。我们确定了三个稳定的症状群：不适症状群（缺乏能量，感觉不舒服，疼痛，恶心，食欲不振），身体症状群（皮肤问题，震颤，视力恶化，味觉改变，呼吸急促，经常感冒）和情绪症状群（感到悲伤，紧张，睡眠问题）。不适和情绪症状群对生活质量的影响大于身体症状群。确定这些症状，除了治疗身体症状本身之外，还需要在心理社会支持方面提供额外的支持。
Autologous haematopoietic cell transplantation (autoHCT) and continuous post‐transplant maintenance therapy are the standard of care in transplant‐eligible multiple myeloma (MM) patients. We sought to describe symptom burden and identify symptom clusters occurring in MM patients after autoHCT using data from the BMT CTN 0702 randomized controlled trial comparing the outcomes of three treatment interventions after an autoHCT in 758 MM patients. We analysed individual transplant‐related symptoms assessed via the FACT‐BMT questionnaire at enrolment and annually for 4‐year post‐autoHCT. We also described the effect the individual symptoms and symptom clusters have on quality of life (QoL). We identified three stable symptom clusters: malaise symptom cluster (lack of energy, feeling ill, having pain, experiencing nausea, loss of appetite), physical symptom cluster (having skin problems, tremors, worsening eyesight, change in taste, shortness of breath, frequent colds) and emotional symptom cluster (feeling sad, being nervous, experiencing sleep problems). Malaise and emotional symptom clusters have a greater impact on QoL than the physical symptoms cluster. Identifying these symptoms warrant additional support in terms of psychosocial support, in addition to treatment of the physical symptoms themselves.