Scintigraphic assessment of salivary gland function in a rat model.
Scintigraphic assessment of salivary gland function in a rat model.
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发表时间：
2010-09
期刊：
影响因子：
2.3
通讯作者：
A. Pfestroff;Felix Müller;D. Librizzi;B. Eivazi;M. Béhé;H. Hoeffken;T. Behr;A. Teymoortash
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作者：
A. Pfestroff;Felix Müller;D. Librizzi;B. Eivazi;M. Béhé;H. Hoeffken;T. Behr;A. Teymoortash
背景唾液腺功能障碍伴口干症是一个主要的临床问题，在大多数病例中没有因果治疗。唾液腺功能显影评估动物模型的建立，对于研究有前景的慢性唾液腺疾病的新诊断和治疗策略具有重要的临床意义。本研究报告了第一次在大鼠模型中对唾液腺功能进行显影分析的经验。材料与方法对Wistar大鼠主要唾液腺的形态分化进行解剖和显影研究。（⁹m）进行高技术酸锝唾液腺扫描，确定合适的感兴趣区域，并检查腺体与背景比以评估唾液腺功能。结果唾液腺显像定量分析显示，双侧大唾液腺比较可靠，腺本比为1.26 ~ 1.94，平均为1.51。结论：该模型似乎适合于实验环境下的功能研究。
BACKGROUND Salivary gland dysfunction with xerostomia is a major clinical problem without a causal therapy in most cases. The development of an animal model for scintigraphic assessment of salivary gland function has great clinical relevance for the investigation of promising new diagnostic and therapeutic strategies for chronic salivary gland diseases. This study reports the first experiences with scintigraphic analyses of salivary gland function in a rat model. MATERIALS AND METHODS Anatomical and scintigraphic studies were performed for topographic differentiation of major salivary glands of Wistar rats. (⁹⁹m)technetium pertechnetate salivary gland scanning was performed, appropriate regions of interest were determined and the gland-to-background ratio was examined for the evaluation of salivary gland function. RESULTS The quantitative analysis of salivary gland scintigraphy revealed a reliable comparison of major salivary glands on both sides with the gland-to-background ratio ranging from 1.26 to 1.94 with an average of 1.51. CONCLUSION This model seems to be appropriate for functional studies in an experimental setting.