Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus.
Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus.
复制标题
肾上腺素减少血红素：对于理解激动剂刺激的传递的意义。
DOI：
10.1126/science.6274020
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
White,JG
中科院分区：
文献类型：
--
作者：
Peterson,DA;Gerrard,JM;Glover,SM;Rao,GH;White,JG
发现促进血小板聚集的α-肾上腺素能激动剂可将亚铁血红素还原为亚铁血红素。与血红素中的铁结合的药物可抑制肾上腺素诱导的血小板聚集。有人提出，肾上腺素首先结合到它的受体，然后减少相邻的血红素基团传递其激动剂刺激。
Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.