The Omega-3 Index: a new risk factor for death from coronary heart disease?
The Omega-3 Index: a new risk factor for death from coronary heart disease?
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DOI：
10.1016/j.ypmed.2004.02.030
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发表时间：
2004-07-01
影响因子：
5.1
通讯作者：
von Schacky, C
中科院分区：
文献类型：
--
作者：
Harris, WS;von Schacky, C
背景二十碳五烯酸和二十二碳六烯酸（EPA + DHA）的低摄入量或血液水平与冠心病（CHD）死亡风险增加独立相关。在随机二级预防试验中，鱼或鱼油已被证明可以降低总死亡率和CHD死亡率，摄入量约为1 g/天。红细胞（RBC）脂肪酸（FA）组成反映了EPA + DHA的长期摄入量。我们建议将RBC EPA + DHA（以下称为Omega-3指数）视为CHD死亡的新风险因素。我们进行了临床和实验室实验，以生成验证Omega-3指数作为CHD风险预测因子所需的数据。然后在几个已发表的一级和二级预防研究中评估了这种假定的标志物与CHD死亡风险，特别是心源性猝死（SCD）风险之间的关系。Omega-3指数与CHD死亡风险呈负相关。Omega-3指数大于或等于8%与最大的心脏保护相关，而指数小于或等于4%与最小相关。Omega-3指数可能代表了一种新的、生理相关的、易于修改的、独立的、分级的冠心病死亡风险因素，可能具有重要的临床实用性。(C)2004年癌症预防研究所和爱思唯尔公司。All rights reserved.
Background. Low intakes or blood levels of eicosapentaenoic and docosahexaenoic acids (EPA + DHA) are independently associated with increased risk of death from coronary heart disease (CHD). In randomized secondary prevention trials, fish or fish oil have been demonstrated to reduce total and CHD mortality at intakes of about 1 g/day. Red blood cell (RBC) fatty acid (FA) composition reflects long-term intake of EPA + DHA. We propose that the RBC EPA + DHA (hereafter called the Omega-3 Index) be considered a new risk factor for death from CHD.Methods. We conducted clinical and laboratory experiments to generate data necessary for the validation of the Omega-3 Index as a CHD risk predictor. The relationship between this putative marker and risk for CHD death, especially sudden cardiac death (SCD), was then evaluated in several published primary and secondary prevention studies.Results. The Omega-3 Index was inversely associated with risk for CHD mortality. An Omega-3 Index of greater than or equal to 8% was associated with the greatest cardioprotection, whereas an index of less than or equal to 4% was associated with the least.Conclusion. The Omega-3 Index may represent a novel, physiologically relevant, easily modified, independent, and graded risk factor for death from CHD that could have significant clinical utility. (C) 2004 The Institute for Cancer Prevention and Elsevier Inc. All rights reserved.