Cardiovascular, hemodynamic, neuroendocrine, and inflammatory markers in women with and without vasomotor symptoms.
Cardiovascular, hemodynamic, neuroendocrine, and inflammatory markers in women with and without vasomotor symptoms.
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患有和没有血管舒缩症状的女性的心血管，血液动力学，神经内分泌和炎症标志物。
DOI：
10.1097/gme.0000000000000689
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Girdler SS
中科院分区：
文献类型：
--
作者：
Gordon JL;Rubinow DR;Thurston RC;Paulson J;Schmidt PJ;Girdler SS
血管痉挛症状（VMS）可能与心血管疾病风险增加有关。一个候选机制可能涉及对压力的生理反应的改变。因此，本研究探讨了自我报告的VMS困扰和心血管，血液动力学，神经内分泌和炎症反应之间的关系，以急性心理社会应激协议。186名处于绝经过渡期或绝经早期的妇女（年龄45-60岁）为本报告提供了数据。使用格林更年期量表评估主观潮热和盗汗困扰。妇女还经历了一个压力电池涉及的讲话和心算任务，而心血管，血液动力学，神经内分泌和炎症反应进行了评估。重复测量回归分析被用来研究自我报告VMS和生理反应的压力之间的关系。在调整潜在混杂因素的多变量分析中，自我报告的潮热困扰与较低的总体心脏指数和每搏输出量指数以及较高的总体血管阻力指数和炎性细胞因子白细胞介素-6水平相关。潮热困扰也倾向于与较高的整体皮质醇水平和较高的血浆去甲肾上腺素基线水平相关。另一方面，夜间出汗困扰与较高的整体皮质醇水平相关，并倾向于与较高的白细胞介素-6相关。自我报告的VMS困扰与不利的血流动力学和神经内分泌特征相关，其特征为下丘脑-垂体-肾上腺轴和中枢交感神经激活增加、炎症和血管收缩。进一步的研究调查这方面的VMS，以及这种关联的潜在健康影响，是必要的。
Vasomotor symptoms (VMS) may be associated with an increased risk of cardiovascular disease. One candidate mechanism may involve alterations in physiological responses to stress. The current study therefore examined the relationship between self-reported VMS bother and cardiovascular, hemodynamic, neuroendocrine and inflammatory responses to an acute psychosocial stress protocol. One hundred and eighty-six women in the menopause transition or early postmenopause (age 45-60) provided the data for this report. Subjective hot flash and night sweat bother was assessed using the Greene Climacteric Scale. Women also underwent a stressor battery involving a speech and a mental arithmetic task while cardiovascular, hemodynamic, neuroendocrine and inflammatory responses were assessed. Repeated measures regression analyses were used to examine the relationship between self-reported VMS and physiologic responses to the stressor. In multivariate analyses adjusting for potential confounders, self-reported hot flash bother was associated with lower overall cardiac index and stroke volume index and higher overall vascular resistance index and levels of the inflammatory cytokine interleukin-6. Hot flash bother also tended to be associated with higher overall cortisol levels and higher baseline levels of plasma norepinephrine. Night sweat bother, on the other hand, was associated with higher overall cortisol levels and tended to be associated with higher interleukin-6. Self-reported VMS bother is associated with an unfavorable hemodynamic and neuroendocrine profile characterized by increased hypothalamic-pituitary-adrenal axis and central sympathetic activation, inflammation and vasoconstriction. Further research investigating this profile in relation to VMS, as well as the potential health implications of this association, are warranted.