The role of surface energy of technical polymers in serum protein adsorption and MG-63 cells adhesion
The role of surface energy of technical polymers in serum protein adsorption and MG-63 cells adhesion
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DOI：
10.1016/j.nano.2009.05.006
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发表时间：
2010-02-01
影响因子：
5.4
通讯作者：
Samitier, Josep
中科院分区：
文献类型：
--
作者：
Comelles, Jordi;Estevez, Maruxa;Samitier, Josep
聚合物材料被广泛用作医学植入物中细胞培养的支持物和组织再生的支架。然而，生物传感器领域的新应用要求材料与细胞生长相容，同时适合于技术处理。高科技聚合物是制造一次性部件和其他传感元件的关键材料。因此，表征技术聚合物的表面特性至关重要，尤其是在加工和灭菌后。了解技术聚合物在与聚合物材料接触时如何影响细胞行为也很重要。因此，本研究的目的是研究表面能和表面粗糙度如何影响广泛用于研究和工业的三种聚合物材料的生物相容性：聚（甲基丙烯酸甲酯），聚苯乙烯和聚（二甲基硅氧烷）。玻璃被用作对照材料。来自临床编辑：聚合物材料被广泛用作医疗植入物中细胞培养的支持物和组织再生的支架。本研究的目的是研究表面能和表面粗糙度如何影响三种广泛用于研究和工业的聚合物材料的生物相容性：聚甲基丙烯酸甲酯（PMMA），聚苯乙烯（PS）和聚二甲基硅氧烷（PDMS）。(C)2010年爱思唯尔公司All rights reserved.
Polymeric materials are widely used as supports for cell culturing in medical implants and as scaffolds for tissue regeneration. However, novel applications in the biosensor field require materials to be compatible with cell growth and at the same time be suitable for technological processing. Technological polymers are key materials in the fabrication of disposable parts and other sensing elements. As such, it is essential to characterize the surface properties of technological polymers, especially after processing and sterilization. It is also important to understand how technological polymers affect cell behavior when in contact with polymer materials. Therefore, the aim of this research was to study how surface energy and surface roughness affect the biocompatibility of three polymeric materials widely used in research and industry: poly (methyl methacrylate), polystyrene, and poly(dimethylsiloxane). Glass was used as the control material.From the Clinical Editor: Polymeric materials are widely used as supports for cell culturing in medical implants and as scaffolds for tissue regeneration. The aim of this research is to study how surface energy and surface roughness affect the biocompatibility of three polymeric materials widely used in research and industry: poly(methylmethacrylate) (PMMA), polystyrene (PS), and poly(dimethylsiloxane) (PDMS). (C) 2010 Elsevier Inc. All rights reserved.