Biochemical engineering's grand adventure
Biochemical engineering's grand adventure
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DOI：
10.1016/j.ces.2016.12.065
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发表时间：
2017-10-12
影响因子：
4.7
通讯作者：
Heijnen, Joseph J.
中科院分区：
文献类型：
--
作者：
Noorman, Henk J.;Heijnen, Joseph J.
基于最近的分子生物学革命，使大量的生物产品创新从可再生原料，生物技术领域是在一个过渡阶段，把产品推向市场。这需要从自然科学转向工程科学，首先是新的，有效的大规模生物工艺设计的概念，其次是在实践中实施最有前途的设计。灵感来自O. Levenspiel在1988年，概述了生物化学工程领域目前面临的主要挑战，在主要的全球可持续发展趋势的背景下。关键阶段是概念设计阶段。处理和克服问题的最佳方法是采取一种从始至终的态度。这适用于三个主要组成部分：1。生物工艺价值链，其中产品规格和下游纯化方案应在定义上游部分之前设定，2.时间视角，从未来开始，假设原料和产品市场组合已经到位，然后回到今天，以及3。操作规模，工业操作为所有实验室规模的研究和开发设定了界限，而不是相反。通过这种方式，考虑到预期制造的约束，定义了理想的过程。为了说明，提供了三个生物过程设计示例，展示了如何生成新的、理想的概念设计。这些也清楚地表明，工程科学正在经历一场革命，基于生物的方法取代了化石路线，粗略的简化被高度详细的计算方法所取代。对于生物化学过程，生命线建模框架被强调为协调生物化学工程在设计和实施阶段对高速度和高质量的竞争需求的有力手段，从而实现生物经济的显着增长。(C)2017作者（S）爱思唯尔有限公司出版
Building on the recent revolution in molecular biology, enabling a wealth of bio-product innovations made from renewable feedstocks, the biotechnology field is in a transition phase to bring the products to the market. This requires a shift from natural sciences to engineering sciences with first conception of new, efficient large-scale bioprocess designs, followed by implementation of the most promising design in practice. Inspired by a former publication by O. Levenspiel in 1988, an outline is presented of main challenges that the field of biochemical engineering is currently facing, in a context of major global sustainability trends. The critical stage is the conceptual design phase. Issues can best be addressed and overcome by adopting an attitude where one begins with the end in mind. This applies to three principal components: 1. the bioprocess value chain, where the product specifications and downstream purification schemes should be set before defining the upstream sections, 2. the time perspective, starting in the future assuming that feedstock and product-market combinations are already in place and then going back to today, and 3. the scale of operation, where the industrial operation sets the boundaries for all lab scale research and development, and not vice versa. In this way, and ideal process is defined taking constraints from anticipated manufacturing into account. For illustration, three bioprocess design examples are provided, that show how new, ideal conceptual designs can be generated. These also make clear that the engineering sciences are undergoing a revolution, where bio-based approaches replace fossil routes, and gross simplification is replaced by highly detailed computational methods. For biochemical processes, lifeline modeling frameworks are highlighted as powerful means to reconcile the competing needs for high speed and high quality in biochemical engineering, both in the design and implementation stages, thereby enabling significant growth of the bio-based economy. (C) 2017 The Author(s). Published by Elsevier Ltd.