Dendritic pathology in prion disease starts at the synaptic spine
Dendritic pathology in prion disease starts at the synaptic spine
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DOI：
10.1523/jneurosci.5062-06.2007
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发表时间：
2007-06-06
影响因子：
5.3
通讯作者：
Herms, Jochen
中科院分区：
文献类型：
--
作者：
Fuhrmann, Martin;Mitteregger, Gerda;Herms, Jochen
脊柱丢失是神经退行性疾病的常见特征。然而，对其潜在机制知之甚少，特别是脊柱消除和神经炎破坏之间的关系。我们成像皮质树突整个神经退行性疾病使用瘙痒鼠为模型。2个月的双光子体内成像显示脊柱密度呈线性下降。有趣的是，只有持久棘（寿命>= 8 d）消失，而瞬态棘（寿命>= 8 d）的密度消失
Spine loss represents a common hallmark of neurodegenerative diseases. However, little is known about the underlying mechanisms, especially the relationship between spine elimination and neuritic destruction. We imaged cortical dendrites throughout a neurodegenerative disease using scrapie in mice as a model. Two-photon in vivo imaging over 2 months revealed a linear decrease of spine density. Interestingly, only persistent spines (lifetime >= 8 d) disappeared, whereas the density of transient spines (lifetime