DISTINCTION BETWEEN HEPATOCELLULAR-CARCINOMA, CHOLANGIOCARCINOMA, AND METASTATIC CARCINOMA BASED ON IMMUNOHISTOCHEMICAL STAINING FOR CARCINOEMBRYONIC ANTIGEN AND FOR CYTOKERATIN-19 ON PARAFFIN SECTIONS
DISTINCTION BETWEEN HEPATOCELLULAR-CARCINOMA, CHOLANGIOCARCINOMA, AND METASTATIC CARCINOMA BASED ON IMMUNOHISTOCHEMICAL STAINING FOR CARCINOEMBRYONIC ANTIGEN AND FOR CYTOKERATIN-19 ON PARAFFIN SECTIONS
复制标题
DOI：
10.1002/path.1711560405
复制
发表时间：
1988-12-01
影响因子：
7.3
通讯作者：
BAVIERA, EE
中科院分区：
文献类型：
--
作者：
BALATON, AJ;NEHAMASIBONY, M;BAVIERA, EE
在石蜡切片上研究了癌胚抗原（CEA）抗血清和细胞角蛋白19（CK19）单克隆抗体作为诊断试剂对肝脏原发性和继发性恶性上皮肿瘤进行鉴别诊断的适用性。使用CEA抗血清，在60%的肝细胞癌中发现阳性胆小管结构。所有胆管癌和66.6%的转移癌CEA呈阳性，但无胆小管染色模式。所有肝细胞癌CK19呈阴性。所有胆管细胞癌和转移癌CK19呈阳性。这种染色特征可能在疑难诊断病例中有所帮助。
An antiserum to carcinoembryonic antigen (CEA) and a monoclonal antibody to cytokeratin 19 (CK 19) were studied for their suitability as diagnostic reagents for the differential diagnosis of primary and secondary malignant epithelial tumours of the liver, on paraffin sections. With the antiserum to CEA, positive bile canalicular structures were found in 60 per cent of the hepatocellular carcinomas. All the cholangiocarcinomas and 66.6 per cent of the metastatic carcinomas were positive for CEA, without displaying a canalicular staining pattern. All the hepatocellular carcinomas were negative for CK 19. All the cholangioceullular carcinomas and the metastatic carcinomas were positive for CK 19. This staining profile may prove helpful in difficult diagnostic cases.