Biological monitoring of environmental exposure to polycyclic aromatic hydrocarbons in subjects living in the vicinity of a creosote impregnation plant
Biological monitoring of environmental exposure to polycyclic aromatic hydrocarbons in subjects living in the vicinity of a creosote impregnation plant
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DOI：
10.1007/s004200100251
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发表时间：
2001-09-01
影响因子：
3
通讯作者：
Weber, JP
中科院分区：
文献类型：
--
作者：
Bouchard, M;Pinsonneault, L;Weber, JP
目的：本研究旨在评估居住在加拿大德尔森杂酚油浸渍厂附近的不吸烟成年受试者对多环芳烃 (PAH) 的环境暴露情况。萘、α-和β-萘酚以及芘代谢物1-羟基芘（1-OHP）的尿液代谢物被用作暴露的生物标志物。方法：8 月中旬，从居住在工厂下风向 50-360 m 的 30 名暴露个体以及居住在工厂上风向 1.9-2.7 km 的邻近城市的对照组收集晨尿和晚间尿液样本。通过气相色谱/质谱法测量代谢物。结果：通过多变量分析考虑可能的混杂变量后，暴露组的α-和β-萘酚排泄值显着高于对照组（P < 0.04）。暴露组和非暴露组的 α-萘酚几何平均浓度（第 5 个和第 95 个百分位数）分别为 2.04（0.55-6.00）和 1.37（0.39-7.02）μ mol/mol 肌酐（晚间样品）和 2.49（0.77-8.43）和 1.17（0.37-6.88）μ mol/mol 肌酐。早上样本的 mol/mol 肌酐。晚上样品的 1-萘酚相应值为 1.78（0.82-3.67）和 1.36（0.63-5.07）μmol/mol 肌酐，早晨样品的 1.94（1.03-4.96）和 1.08（0.49-5.05）μmol/mol 肌酐。另一方面，暴露组和对照组之间1-OHP排泄量没有观察到显着差异（P>0.5）。这些组的 1-OHP 几何平均浓度（第 5 个百分位数和第 95 个百分位数）对于晚上样品来说分别为 0.05（0.01-0.17）和 0.06（0.01-0.48）μ mol/mol 肌酐，对于晚上样品来说分别为 0.05（0.02-0.12）和 0.05（0.01-0.42）μ mol/mol 肌酐。早上的样品。结论：α-萘酚和 β-萘酚尿浓度的测量似乎是一种足够灵敏的方法，足以揭示杂酚油浸渍工厂排放造成的挥发性 PAH 低暴露水平的差异。然而，植物对芘的吸收量太小，无法对 1-OHP 排泄产生显着贡献。
Objective: This study was undertaken to evaluate the environmental exposure to polycyclic aromatic hydrocarbons (PAHs) in nonsmoking adult subjects living in the vicinity of a creosote impregnation plant in Delson, Canada. Urinary metabolites of naphthalene, alpha- and beta -naphthol, and pyrene metabolite 1-hydroxypyrene (1-OHP), were used as biomarkers of exposure. Methods: Morning and evening urine samples were collected in mid-August from 30 exposed individuals living at a distance of 50-360 m downwind of the plant and from a control group in the adjoining municipality residing at a distance of 1.9-2.7 km upwind of the plant. Metabolites were measured by gas chromatography/mass spectrometry. Results: Excretion values of alpha- and beta -naphthol were significantly higher in the exposed group than in controls (P < 0.04), after accounting for possible confounding variables by multivariate analyses. The respective geometric mean concentrations (5th and 95th percentiles) of alpha -naphthol for the exposed and nonexposed groups were 2.04 (0.55-6.00) and 1.37 (0.39-7.02) mu mol/mol creatinine for evening samples, and 2.49 (0.77-8.43) and 1.17 (0.37-6.88) mu mol/mol creatinine for morning samples. Corresponding values for fl-naphthol were 1.78 (0.82-3.67) and 1.36 (0.63-5.07) mu mol/mol creatinine for evening samples, and 1.94 (1.03-4.96) and 1.08 (0.49-5.05) mu mol/mol creatinine for morning samples. On the other hand, no significant difference in 1-OHP excretion was observed between the exposed and the control group (P >0.5). The respective geometric mean concentrations (5th and 95th percentiles) of 1-OHP for these groups were 0.05 (0.01-0.17) and 0.06 (0.01-0.48) mu mol/mol creatinine for evening samples, and 0.05 (0.02-0.12) and 0.05 (0.01-0.42) mu mol/mol creatinine for morning samples. Conclusions: The measurement of alpha- and beta -naphthol urinary concentrations appears to be an approach sufficiently sensitive to reveal differences in low exposure levels of volatile PAHs due to creosote impregnation plant emissions. However, uptake of pyrene due to the plant was too small to contribute significantly to 1-OHP excretion.