Known unknowns for allele-specific expression and genomic imprinting effects.
Known unknowns for allele-specific expression and genomic imprinting effects.
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DOI：
10.12703/p6-75
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Gregg C
中科院分区：
文献类型：
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作者：
Gregg C
最近的研究提供了证据，非典型的印迹效应，与等位基因特异性表达的偏见在组织水平上在小鼠。这些印记效应具有与涉及等位基因沉默的典型印记效应不同的特征。在这里，我讨论了一些证据的背景下，随机X-失活和表观遗传等位基因特异性表达的常染色体上的非典型印迹效应。我提出了几种机制，可能是非典型的印迹效应和概述未来的方向和方法，在体内细胞水平上研究这些影响。越来越多的证据表明，复杂的等位基因特异性表达效应是细胞和发育阶段特异性的，这为研究开辟了一个新的前沿。目前，这些效应的功能和潜在的调节机制在很大程度上是未知的。
Recent studies have provided evidence for non-canonical imprinting effects that are associated with allele-specific expression biases at the tissue level in mice. These imprinting effects have features that are distinct from canonical imprinting effects that involve allele silencing. Here, I discuss some of the evidence for non-canonical imprinting effects in the context of random X-inactivation and epigenetic allele-specific expression effects on the autosomes. I propose several mechanisms that may underlie non-canonical imprinting effects and outline future directions and approaches to study these effects at the cellular level in vivo. The growing evidence for complex allele-specific expression effects that are cell- and developmental stage-specific has opened a new frontier for study. Currently, the function of these effects and the underlying regulatory mechanisms are largely unknown.