Effects of the CRF1 antagonist SSR125543A on aggressive behaviors in hamsters
Effects of the CRF1 antagonist SSR125543A on aggressive behaviors in hamsters
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DOI：
10.1016/j.pbb.2003.12.023
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发表时间：
2004-03-01
影响因子：
3.6
通讯作者：
Blanchard, RJ
中科院分区：
文献类型：
--
作者：
Farrokhi, C;Blanchard, DC;Blanchard, RJ
促肾上腺皮质激素释放因子 (CRF) 及其受体亚型与内分泌和对压力和情绪（包括恐惧、焦虑和攻击性）的行为反应有关。 SSR 125543A 是一种新的 CRF1 受体非肽选择性拮抗剂，已被证明在许多焦虑动物模型中产生抗焦虑样作用。本研究调查了口服剂量 10 或 30 mg/kg 的 SSR 125543A 对居住的雄性叙利亚仓鼠对雄性入侵者的攻击行为的影响。高剂量（30 mg/kg）的 CRF I 受体拮抗剂产生较高的咬合潜伏期、较低的横向攻击频率和追逐持续时间，表明常驻仓鼠对入侵者的攻击性减少。相同剂量的 SSR 125543A 还增加了嗅觉调查的频率和持续时间，表明回避对手或缺乏社交活动都不是这些动物攻击性减少的原因。 (C) 2004 Elsevier Inc. 保留所有权利。
Corticotropin-releasing factor (CRF) and its receptor subtypes have been implicated in endocrine and behavioral responsivity to stress and emotion, including fear, anxiety, and aggression. SSR 125543A is a new nonpeptide selective antagonist at the CRFl receptor that has been shown to produce an anxiolytic-like effect in a number of animal models of anxiety. The present study investigated effects of an oral dose of 10, or 30 mg/kg of SSR 125543A on aggressive behaviors of resident male Syrian hamsters toward male intruders. The high dose (30 mg/kg) of the CRF I receptor antagonist produced a higher latency to bite and lower lateral attack frequencies and chase durations, indicating a reduction in aggression toward intruders in resident hamsters. The same dose of SSR 125543A also enhanced frequency and duration of olfactory investigation, indicating that neither avoidance of the opponent nor deficiency in social activity is responsible for the reduction in aggression seen in these animals. (C) 2004 Elsevier Inc. All rights reserved.