Altered serum levels of type I collagen turnover indicators accompanied by IL-6 and IL-8 release in stable COPD
Altered serum levels of type I collagen turnover indicators accompanied by IL-6 and IL-8 release in stable COPD
复制标题
稳定期 COPD 患者血清 I 型胶原蛋白周转指标水平发生改变，并伴有 IL-6 和 IL-8 释放
DOI：
10.2147/copd.s188139
复制
发表时间：
2019-01-01
影响因子：
2.8
通讯作者：
Zhang, Jing
中科院分区：
文献类型：
--
作者：
Zeng, Ying-Ying;Hu, Wei-Ping;Zhang, Jing
COPD以慢性炎症和气道重塑为特征，在细胞外基质的组成和沉积方面有明显的病理改变。前胶原1 c末端肽（PICP）和1型胶原c末端末端肽（ICTP）是胶原合成和降解的两种主要副产物，其表达与炎症介质水平呈正相关。目的本研究探讨稳定期COPD患者血清PICP和ICTP浓度与炎症水平的相关性。患者与方法采集2011年12月至2012年10月在上海中山医院和上海大华医院就诊的25例对照和20例稳定期COPD患者的血清样本。采用酶联免疫吸附法测定PICP、ICTP、c反应蛋白（CRP）、IL-6、IL-8和肿瘤坏死因子(TNF)-α的浓度。结果两组患者人口学特征具有可比性。稳定期COPD患者血清CRP、IL-6、IL-8、TNF-α水平均较对照组升高，但仅有IL-6变化有统计学意义。COPD患者血清PICP浓度显著升高，ICTP水平轻度降低。此外，血清PICP浓度与IL-6和IL-8水平呈正相关。结论COPD患者血清PICP水平升高可能提示气道重构，IL-6和/或IL-8可能在促进胶原合成中起重要作用。
Background COPD, characterized by chronic inflammation and airway remodeling, has significant pathological alterations in composition and deposition of the extracellular matrix. The expression of procollagen 1 C-terminal peptide (PICP) and collagen type 1 C-terminal telopeptide (ICTP), two major by-products in the synthesis and degradation of collagen, was shown to be positively correlated with inflammatory mediator levels in previous studies. Purpose In this study, we investigated whether the serum concentrations of PICP and ICTP were associated with the inflammation level for patients with stable COPD. Patients and methods We collected serum samples from 25 control subjects and 20 patients with stable COPD from December 2011 to October 2012 in Shanghai Zhongshan Hospital and Shanghai Dahua Hospital. We determined concentrations of PICP, ICTP, C-reactive protein (CRP), IL-6, IL-8, and tumor necrosis factor (TNF)-α by using enzyme-linked immunosorbent assay methods. Results Demographic characteristics were comparable between the two groups. In patients with stable COPD, serum levels of CRP, IL-6, IL-8, and TNF-α were all elevated compared to control subjects, but only changes of IL-6 achieved statistical significance. Serum concentration of PICP was significantly elevated in patients with COPD, and level of ICTP was slightly decreased. Moreover, serum concentrations of PICP were positively correlated with the levels of both IL-6 and IL-8. Conclusion The increased levels of serum PICP in COPD might indicate the condition of airway remodeling, and IL-6 and/or IL-8 might play an important role in stimulating collagen synthesis.