Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation.
Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation.
复制标题
大鼠海马结构中的神经生长因子免疫反应性和交感神经出芽。
DOI：
10.1016/0006-8993(94)01344-h
复制
发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Crutcher,KA
中科院分区：
文献类型：
--
作者：
Yu,C;Crutcher,KA
Several lines of evidence support a role for nerve growth factor (NGF) in the sympathetic sprouting response that occurs following septal cholinergic denervation of the rat hippocampal formation. The present study was undertaken to compare the distribution of NGF-like immunoreactivity and the topography of sympathetic sprouting in rats receiving medial septal lesions. Comparisons were made using adjacent sections of the hippocampal formation stained either for NGF-like immunoreactivity or for NGF receptor-immunoreactivity (p75, to visualize sympathetic fibers). p75-immunoreactive sympathetic axons were localized within the same regions exhibiting NGF-like staining, i.e., the hilus of the dentate gyrus and stratum lucidum in the CA3 area. Furthermore, the sympathetic fibers that invaded the hippocampal formation exhibited NGF-like immunostaining. These results provide additional evidence in support of NGF's role in this collateral sprouting response in the mature rat CNS.
