Oxidative damage in foundry workers occupationally co-exposed to PAHs and metals
Oxidative damage in foundry workers occupationally co-exposed to PAHs and metals
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DOI：
10.1016/j.ijheh.2009.12.005
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发表时间：
2010-03-01
影响因子：
6
通讯作者：
Chen, Hsiu-Ling
中科院分区：
文献类型：
--
作者：
Liu, Hung-Hsin;Lin, Ming-Hsiu;Chen, Hsiu-Ling
据报道，铸造车间职业暴露于多环芳烃(PAHs)。在职业接触多环芳烃的人群中，也发现DNA损伤或氧化损伤的风险更高。这项研究的目的是通过尿中生物接触标志物1-羟基芘(1-OHP)的排泄来评估多环芳烃暴露。此外，我们旨在评估不同工作任务的铸造工人的氧化损伤，以及接触普遍致癌物质的铸造工人1-OHP、金属暴露与氧化损伤之间的关系。暴露组1-OHP浓度(0.322+/-0.289 mU/g肌酐)高于对照组(0.178/-0.289 mU/g肌酐)(p<；0.05)。此外，参与制造过程的工人(0.346微克/克肌酐)比行政人员(0.018微克/克肌酐)的1-OHP水平更高。在所有研究对象中，1-OHP和8-羟基脱氧鸟苷(8-OH-DG)水平、DNA链断裂和丙二醛(MDA)水平呈正相关。然而，当根据铸造工人的特定工种考虑时，1-OHP和三种氧化损伤标记物的趋势相似，仅在DNA链断裂方面，而对8-OH-DG或丙二醛没有发现。其他因素，如炉膛设备、多环芳烃类型和工作类别，可能会导致不同的多环芳烃排放。研究还表明，金属和多环芳烃的共同暴露以及铸造行业的吸烟状况也可能导致铸造工人的氧化损伤。(C)2009年爱思唯尔股份有限公司。版权所有。
Occupational exposure to polycyclic aromatic hydrocarbons (PAHs) has been reported in foundries. A higher risk for DNA damage or oxidative damage lesions was also found in occupationally PAH-exposed groups. The aim of this study was to assess PAH exposure by urinary excretion of 1-hydroxypyrene (1-OHP), a biological exposure marker. Furthermore, we aimed to evaluate the oxidative damage of foundry workers with different job tasks and the association between 1-OHP, metal exposure and oxidative damage in foundry workers exposed to pervasive carcinogens.A higher concentration of 1-OHP was found in the exposed group (0.322 +/- 0.289 mu g/g creatinine) relative to the control group (0.178 +/- 0.289 mu g/g creatinine) (p < 0.05). Moreover, higher levels of 1-OHP were found in workers involved in manufacturing processes (0.346 mu g/g creatinine) compared to administrative workers (0.018 mu g/g creatinine). A positive correlation was identified between levels of 1-OHP and 8-hyclroxydeoxyguanosine (8-OH-dG), DNA strand breakage and malondialdehyde (MDA) in all study subjects. However, when foundry workers were considered based on their specific job categories, a similar trend for 1-OHP and three oxidative damage markers was only found for DNA strand breakage, but not for 8-OH-dG or MDA. Other factors such as furnace equipment, PAH types, and job categories may contribute to different PAH emissions. The study also suggested that co-exposure to metal and PAHs, and smoking status in foundry industries may also cause the oxidative damage in foundry workers. (C) 2009 Elsevier GmbH. All rights reserved.