Humans respond predominantly with IgM immunoglobulin to the species-specific glycolipid of Mycobacterium leprae.
Humans respond predominantly with IgM immunoglobulin to the species-specific glycolipid of Mycobacterium leprae.
复制标题
人类主要通过 IgM 免疫球蛋白对麻风分枝杆菌的物种特异性糖脂做出反应。
DOI：
10.1093/infdis/149.6.870
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
T. Buchanan
中科院分区：
文献类型：
--
作者：
D. Young;S. Dissanayake;R. Miller;S. Khanolkar;T. Buchanan
已对 78 名麻风病患者的血清样本中针对麻风分枝杆菌物种特异性酚糖脂抗原的抗体反应的免疫球蛋白类别进行了表征。这些患者包括从少杆菌到多杆菌疾病的整个临床谱系，包括极类结核（TT；11 名患者）、交界性结核（BT；15 例）、交界性（BB；17）、交界性麻风病（BL；13）和麻风病（LL；22）——根据 Ridley-Jopling 标准进行临床分类。在每个患者组中，酚糖脂IgM抗体水平显着高于IgG或IgA水平。使用纯化抗原进行的抑制实验表明，针对麻风分枝杆菌表面的人类 IgM 抗体反应主要是针对酚糖脂的抗体。
The immunoglobulin classes of the antibody response to the species-specific phenolic glycolipid antigen of Mycobacterium leprae have been characterized for serum specimens from 78 patients with leprosy. These patients included the entire clinical spectrum from paucibacillary to multibacillary disease, including polar tuberculoid (TT; 11 patients), borderline tuberculoid (BT; 15), borderline (BB; 17), borderline lepromatous (BL; 13), and lepromatous (LL; 22)--clinical classifications according to Ridley-Jopling criteria. In each patient group, the levels of IgM antibody to phenolic glycolipid were significantly higher than levels of IgG or IgA. Inhibition experiments with purified antigen showed that antibodies to the phenolic glycolipid dominated the human IgM antibody response to the surface of M. leprae.