Gly143Glu polymorphism of the human carboxylesterase1 gene in an Asian population.
Gly143Glu polymorphism of the human carboxylesterase1 gene in an Asian population.
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亚洲人群中人类羧酸酯酶 1 基因的 Gly143Glu 多态性。
DOI：
10.1007/s00228-012-1352-0
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Suzaki Yuki
中科院分区：
文献类型：
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作者：
Nishibori M;Liu K;Okuma Y;Wake H;Teshigawara K;Takahashi H;Date I;Mori S;Suzaki Yuki
正如朱博士和马科维茨博士在他们的信中所评论的那样，人们普遍认为羧酸酯酶（CES）是一种重要的酶，可以在体内激活前药。在我们的报告中，观察到的奥司他韦代谢的个体间差异不能根据CES1A1基因型和CES1功能基因[1]的数量来解释。然而，在我们的研究中，奥司他韦对一名受试者的曲线下面积（AUC）比其他受试者的相应AUC高约10倍。
Dear Editor, As Drs Zhu and Markowitz commented in their letter, it is widely recognized that carboxylesterase (CES) is an important enzyme that activates prodrugs in vivo. In our report, the interindividual variability observed in the metabolism of oseltamivir could not be explained on the basis of the CES1A1 genotypes and the number of CES1 functional genes [1]. However, the area under the curve (AUC) for oseltamivir for one subject in our study was approximately 10-fold higher than the corresponding AUCs for the rest of the subjects.