Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging
Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging
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通过同步近红外-I/II 成像和谷胱甘肽清除，阐明铂的运输，同时最大限度地提高金纳米团簇的治疗效果
DOI：
10.1021/acsnano.0c05541
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发表时间：
2020-10-27
期刊：
影响因子：
17.1
通讯作者：
Yu, Zhiqiang
中科院分区：
文献类型：
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作者：
Yang, Yuanyuan;Yu, Yingjie;Yu, Zhiqiang
利用可视化系统杀死肿瘤细胞是一种很有前途的治疗肿瘤的策略，以达到最小的副作用和高效率。本文基于纳米载体金纳米团簇（AuNCs）开发了一种治疗性纳米药物（AuNCs- pt），具有NIR-I/NIR-II成像和谷胱甘肽清除能力的双重功能。AuNCs-Pt具有NIR-II成像能力，可用于深腹部致死的高级别浆液性卵巢癌（HGSOC）模型，从而使其成为一种有前景的监测铂运输的工具。同时，AuNCs-Pt消耗细胞内谷胱甘肽，减少铂的解毒，有效地最大化铂的化疗疗效。本研究在HGSOC模型和患者源性肝癌异种移植模型中使用AuNCs-Pt消除肿瘤负担，提示其在临床可视化治疗和铂类药物增敏方面具有很大的潜力。
Killing tumor cells with a visualized system is a promising strategy in tumor therapy to achieve minimal side effects and high efficiency. Herein, a theranostic nanomedicine (AuNCs-Pt) is developed based on nanocarrier gold nanoclusters (AuNCs) with bifunctions of both NIR-I/NIR-II imaging and glutathione-scavenging abilities. AuNCs-Pt possesses NIR-II imaging capability on a fatal high-grade serous ovarian cancer (HGSOC) model in the deep abdomen, thus facilitating it to be a promising tool for monitoring platinum transportation. Meanwhile, AuNCs-Pt depletes intracellular glutathione to minimize platinum detoxification, effectively maximizing the chemotherapeutic efficacy of platinum. AuNCs-Pt is used to eradicate the tumor burden in this study on a HGSOC model and a patient-derived tumor xenograft model of hepatocellular carcinoma, suggesting great potential for clinical visualized therapy and platinum drug sensitization.