Fungemia due to Trichosporon asahii in a neutropenic child refractory to amphotericin B -: Clearance with voriconazole
Fungemia due to Trichosporon asahii in a neutropenic child refractory to amphotericin B -: Clearance with voriconazole
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DOI：
10.1097/01.mph.0000164865.70522.d7
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发表时间：
2005-05-01
影响因子：
1.2
通讯作者：
Roilides, E
中科院分区：
文献类型：
--
作者：
Antachopoulos, C;Papakonstantinou, E;Roilides, E
中性粒细胞减少患者的弥散性三磷酸腺苷感染预后较差。使用伏立康唑治疗这种感染的临床证据有限。作者报告了一例急性淋巴细胞白血病男孩的阿希毛孢菌血症对两性霉素B脂质体治疗难治性，在添加伏立康唑后消退。伏立康唑和两性霉素B均表现出较低的最低抑菌浓度和最低杀真菌浓度，其组合在体外无显著差异。伏立康唑治疗血液系统恶性肿瘤患者的三磷血症值得进一步研究。
Disseminated Trichosporon infection in neutropenic patients carries a poor prognosis. Clinical evidence on the use of voriconazole for this infection is limited. The authors report a case of Trichosporon asahii fungemia refractory to liposomal amphotericin B treatment in a boy with acute lymphoblastic leukemia, which resolved after the addition of voriconazole. Both voriconazole and amphotericin B exhibited low minimal inhibitory concentrations and minimal fungicidal concentrations, and their combination was indifferent in vitro. The use of voriconazole for the treatment of trichosporonosis in patients with hematologic malignancies deserves further study.