Membrane potential generation without ion transport
Membrane potential generation without ion transport
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无需离子传输即可产生膜电位
DOI：
10.1007/s11581-014-1333-7
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发表时间：
2015
期刊：
影响因子：
2.8
通讯作者：
Hirohisa Tamagawa
中科院分区：
文献类型：
--
作者：
佐藤貴弘;大石佳苗;児島将康;児島将康（分担）;Hirohisa Tamagawa
目前关于细胞的观点认为，细胞是一种覆盖有半透膜的水溶液，在半透膜上存在非零电位，即所谓的膜电位。Goldman-Hodgkin-Katz方程和Donnan理论是现有的解释膜电位产生原因的基本理论。然而，在过去的半个多世纪里，少数研究人员反复报道了这些现有理论无法解释的膜电位观测结果。因此，重新考虑膜电位的产生机制是不言而喻的。根据本文的实验结果，得出结论：现有的理论对膜电位产生的解释是不正确的。相反，吸附理论只是一个真正正确的理论。吸附理论描述了可移动离子在膜上的吸附位置上的吸附产生膜电位。这项工作介绍了用Goldman-Hodgkin-Katz方程或Donnan理论无法解释的实验观察结果，但与吸附理论是一致的。
Current view about cell is that the cell is a watery solution coated with semi-permeable membrane and there exists nonzero potential, so-called membrane potential, across the semi-permeable cell membrane. Goldman-Hodgkin-Katz equation and Donnan theory are the fundamental existing theories for explaining the cause of membrane potential generation. However, the observations of membrane potential inexplicable by these existing theories have been repeatedly reported by a small number of researchers for more than the past half century. Hence, it is needless to say important to reconsider the membrane potential generation mechanism. Based on the experimental result shown in this paper, it was concluded that the existing theories were not genuinely right for the explanation of membrane potential generation. Adsorption theory is only a genuinely right theory instead. The adsorption theory describes that the adsorption of the mobile ions on the adsorption sites on the membrane generates the membrane potential. This work introduces the experimental observation inexplicable by Goldman-Hodgkin-Katz equation or Donnan theory but is in harmony with the adsorption theory.