Brain Natriuretic Peptide and Particular Left Ventricle Segment Asynergy Associated with Cardioembolic Stroke from Old Myocardial Infarction
Brain Natriuretic Peptide and Particular Left Ventricle Segment Asynergy Associated with Cardioembolic Stroke from Old Myocardial Infarction
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DOI：
10.1016/j.jstrokecerebrovasdis.2016.02.003
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发表时间：
2016-05-01
影响因子：
2.5
通讯作者：
Matsumoto, Masayasu
中科院分区：
文献类型：
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作者：
Hosomi, Naohisa;Yoshimoto, Takeshi;Matsumoto, Masayasu
背景资料：通过确定陈旧性心肌梗死患者心源性卒中的实际风险来确定抗凝剂的使用是很重要的。在本研究中，我们旨在使用16节段模型更精确地评估与心源性栓塞性卒中相关的每个节段的风险。与心源性栓塞性卒中相关的血浆脑钠肽（BNP）的使用也与左心室射血分数小于40%进行了比较。方法：190例缺血性脑卒中患者，发病前有心肌梗死。该研究共纳入了143例可供评估的伴有陈旧性心肌梗死的缺血性卒中患者，排除了房颤或急性心肌梗死患者。分析两组患者入院时左室壁运动异常及血浆BNP水平。结果如下：高血压和血浆BNP水平≥ 206.9 pg/mL（根据受试者工作特征曲线测定）与心源性卒中独立相关（卡方2 = 35.6，R-2 = 0.30，P
Background: It is important to determine the usage of anticoagulants by defining the actual risk of cardioembolic stroke in patients with old myocardial infarction. In the present study, we aimed to more precisely evaluate the risks of each segment associated with cardioembolic stroke using a 16-segment model. The usage of the plasma brain natriuretic peptide (BNP) associated with cardioembolic stroke was also evaluated in comparison with a left ventricle ejection fraction less than 40%. Methods: There were a total of 190 ischemic stroke patients who had premorbid myocardial infarction. The study included a total of 143 ischemic stroke patients with old myocardial infarction who were available for evaluation and excluded patients with atrial fibrillation or acute myocardial infarction. Their left ventricle wall motion abnormality and the level of plasma BNP at their admission were analyzed. Results: Hypertension and a plasma BNP level of 206.9 pg/mL or higher, determined from the receiver operating characteristic curve, were independently associated with cardioembolic stroke (chi(2) = 35.6, R-2 =.30, P