Co-circulation of H5N6, H3N2, H3N8, and Emergence of Novel Reassortant H3N6 in a Local Community in Hunan Province in China.
Co-circulation of H5N6, H3N2, H3N8, and Emergence of Novel Reassortant H3N6 in a Local Community in Hunan Province in China.
复制标题
H5N6、H3N2、H3N8 在中国湖南省当地社区的共同传播以及新型重组 H3N6 的出现
DOI：
10.1038/srep25549
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发表时间：
2016-05-06
影响因子：
4.6
通讯作者：
Zhu Q
中科院分区：
文献类型：
--
作者：
Li X;Yang J;Liu B;Jia Y;Guo J;Gao X;Weng S;Yang M;Wang L;Wang LF;Cui J;Chen H;Zhu Q
禽流感病毒（avian influenza virus，AIV）在家禽或野鸟中的多次感染，促进了H5亚型病毒在自然界的持续进化，并为不同来源的AIV提供了潜在的重组机会。在这项研究中，我们从2014-2015年在中国湖南省的鸭，鹅和社区环境中进行了AIV的监测。我们分离了多种共循环的AIV，包括H3 N2，H3 N8和H5 N6，最重要的是，一种新的抑制剂：H3 N6。系统发育分析表明，H3 N6很可能来自H5 N6，最近已被证明具有人畜共患病的潜力与人类感染。用哺乳动物细胞系和小鼠模型进行的研究表明，四种选择的鸭或鹅源AIV可以感染MDCK和A549细胞，但在小鼠中具有低致病性。我们认为，包括H5 N6在内的多个亚型在局部地区可能存在共同循环，可能导致通过基因重排产生新的亚型，如H3 N6。
Multiple infections of avian influenza viruses (AIVs) in poultry or wild birds contribute to the continued evolution of H5 subtype viruses in nature and provide potential recombination of AIVs of different origins. In this study, we carried out surveillance of AIVs in ducks, geese and the environment of a community in Hunan province, China, from 2014–2015. We isolated multiple co-circulated AIVs including H3N2, H3N8 and H5N6, and, most importantly, a novel reassortant: H3N6. Phylogenetic analyses suggest that H3N6 is highly likely derived from H5N6, which has recently been shown to have zoonotic potential with human infections. Studies with mammalian cell lines and a mouse model indicate that four selected AIVs of duck or goose origin can infect MDCK and A549 cells but have low pathogenicity in mice. We propose that a potential co-circulation of multiple subtypes including H5N6 in local area may result in the production of novel subtypes such as H3N6 by gene reassortment.