Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial
Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial
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DOI：
10.1007/s00213-012-2848-0
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发表时间：
2013-02-01
影响因子：
3.4
通讯作者：
Yusoff, Noor Aini Mohd
中科院分区：
文献类型：
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作者：
Lee, Lai Kuan;Shahar, Suzana;Yusoff, Noor Aini Mohd
流行病学研究表明，鱼油补充剂在阻止阿尔茨海默病的初步进展方面具有有益作用。然而，目前尚不清楚鱼油是否会影响轻度认知障碍（MCI）老年人的认知功能。本研究调查了鱼油补充剂对MCI老年人认知功能的影响。这是一项为期12个月的随机、双盲、安慰剂对照研究，使用鱼油补充剂和浓缩二十二碳六烯酸（DHA）。36名社会经济地位较低的轻度认知障碍老年受试者被随机分配接受浓缩二十二碳六烯酸鱼油（n = 18）或安慰剂（n = 18）胶囊。采用认知测验评估记忆、心理速度、执行功能和注意力以及视觉建构技能的变化。第二个结果是DHA浓缩物的安全性和耐受性。鱼油组在短期记忆和工作记忆方面表现出显着的改善（F = 9.890; eta p（2）= 0.254; p < 0.0001），即时言语记忆（F = 3.715; eta p（2）= 0.114; p < 0.05）和延迟回忆能力（F = 3.986; eta p（2）= 0.121; p < 0.05）。鱼油组12个月的记忆变化（p < 0.01）明显更好。食用鱼油耐受性良好，副作用极小且自限。本研究提示鱼油对改善MCI受试者记忆功能具有潜在作用。在做出明确的建议之前，应该对更大样本量、更长干预期、不同鱼油剂量和遗传测定的研究进行调查。
Epidemiological studies have suggested a beneficial effect of fish oil supplementation in halting the initial progression of Alzheimer's disease. However, it remains unclear whether fish oil affects cognitive function in older people with mild cognitive impairment (MCI).This study investigated the effects of fish oil supplementation on cognitive function in elderly person with MCI.This was a 12-month, randomised, double-blind, placebo-controlled study using fish oil supplementation with concentrated docosahexaenoic acid (DHA). Thirty six low-socioeconomic-status elderly subjects with MCI were randomly assigned to receive either concentrated DHA fish oil (n = 18) or placebo (n = 18) capsules. The changes of memory, psychomotor speed, executive function and attention, and visual-constructive skills were assessed using cognitive tests. Secondary outcomes were safety and tolerability of the DHA concentrate.The fish oil group showed significant improvement in short-term and working memory (F = 9.890; eta p (2) = 0.254; p < 0.0001), immediate verbal memory (F = 3.715; eta p (2) = 0.114; p < 0.05) and delayed recall capability (F = 3.986; eta p (2) = 0.121; p < 0.05). The 12-month change in memory (p < 0.01) was significantly better in the fish oil group. Fish oil consumption was well tolerated, and the side effects were minimal and self-limiting.This study suggested the potential role of fish oil to improve memory function in MCI subjects. Studies with larger sample sizes, longer intervention periods, different fish oil dosages and genetic determinations should be investigated before definite recommendations can be made.